t that there are actually two versions
of cyclooxygenase found in the body: COX-1 and COX-2. "COX-2 is induced at areas
of inflammation," explains Laine, "while COX-1 is involved in the day-to-day
maintenance of the stomach lining. What we have seen is that you can get
anti-inflammatory effects by inhibiting COX-2, but you decrease or prevent the
development of gastrointestinal tract injury by sparing COX-1."
In April, a Food and Drug Administration advisory committee recommended approval
of rofecoxib for treatment of osteoarthritis and acute pain. The brand name of
rofecoxib will be Vioxx, according to Merck & Co., which manufactures the drug.
It is likely that the drug will be approved to treat not only osteoarthritis,
but acute pain as well. If given the go-ahead, it will be only the second COX-2
inhibitor on the market.
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Contact: Lori Oliwenstein
University of Southern California
. Stomach pacemaker in use at Temple