New Approach To Attacking Alzheimer's Disease Studied

Researchers have developed an array of new chemicals that may attack Alzheimer's disease in a unique way. The compounds target a little understood enzyme called butyrylcholinesterase, which has recently been shown to be elevated in the brains of patients with AD.

Details about the research will appear in the Journal of Medicinal Chemistry, published by the American Chemical Society (ACS), the world's largest scientific society. The paper became available on the ACS Web May 4 and will be in the journal's May 20 print edition.

Alzheimer's disease is the fourth leading cause of death in Western countries and is a cause of severe dementia in at least four million Americans. Those over 85 years of age, the fastest growing portion of the U.S. population, have a fifty-fifty chance of developing the disease.

One characteristic of Alzheimer's disease is decreased amounts of acetylcholine, a brain signaling chemical which plays a critical role in memory processing. After doing its job, acetylcholine is normally inactivated by enzymes called cholinesterases, which come in two forms and are found throughout the body. The first, acetylcholinesterase (AChE), works at nerve endings; current Alzheimer's disease drugs aim to temporarily disable it. The role of the other form, butyrylcholinesterase (BChE), is largely unknown. "Consequently, there has been minimal interest (among drug makers) in the design, synthesis and development of butyrylcholinesterase inhibitors," says the study's co-author Nigel H. Greig, Ph.D., from the National Institute on Aging's Intramural Research Program. The Institute's Qian-sheng Yu, Ph.D., is lead author on the paper.

While some current drugs randomly inhibit both AChE and BChE, Greig says those tend to have more side effects. He adds that "the present study represents the first to develop highly selective inhibitors of BChE alone with appropriate characteristics for use in animals and humans." Recent laboratory studies h

Contact: Charmayne Marsh
American Chemical Society

Page: 1 2

Related medicine news :

1. Approach of holidays has no effect on time of death
2. Approaches to preventing, treating and living with macular degeneration discussed at Academy meeting
3. Progress In Cancer-Vaccine Studies: Simpler, Safer Approach Producing Encouraging Results
4. New Approach To Multidrug Resistance
5. Attacking bipolar disorder in young adults boosts outcome, says Stanford study
6. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
7. Neuronal death and processing of Tau protein in Alzheimers disease
8. Researchers discover link between insulin and Alzheimers
9. New trials for counseling caregivers and patients with Alzheimers begin
10. Marijuana ingredient may stall decline from Alzheimers
11. Drugs used to treat Alzheimers in nursing homes are worsening sufferers illness

Post Your Comments:

(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: