New Concepts Proposed To Investigate Drug Reactions

A University of Toronto professor is proposing two new concepts to help better understand the cause of adverse drug reactions.

Jack Uetrecht of the Faculty of Pharmacy says that the leading theory on the cause of these reactions -- that the drug irreversibly binds to proteins or other large molecules which are then perceived as foreign and induce an immune response -- doesn't explain many of the key features of such reactions, including why the response only produces symptoms in some people.

He suggests that researchers consider the "danger hypothesis," which states that the immune system only responds to foreign substances if they appear to cause some sort of damage leading to a danger signal, rather than sticking to the traditional view that the immune system will attack anything foreign. Uetrecht says that researchers should also look at the innate immune system and not just focus on the more specific adaptive immune system. The innate system, which is associated with more primitive organisms but also present in humans, doesn't produce antibodies to foreign substances so if a drug causes cell damage it could provoke a response without leaving any of the evidence that researchers usually associate with an immune response.

"These concepts have the potential to lead to a better understanding of hypersensitivity reactions which in turn could lead to the development of tests to predict which drugs will be associated with such reactions, and as well which patients are likely to react to particular drugs," says Uetrecht.

The research, which was supported by the Medical Research Council of Canada, is published in the May issue of Chemical Research in Toxicology.


Contact: Kerry Delaney
University of Toronto

Page: 1

Related medicine news :

1. Proposed addiction treatment successful, safe in second small trial
2. Proposed addiction treatment successful, safe in second small trial
3. Adverse Drug Reactions Are Under Reported
4. Beware Of Adverse Drug Reactions

Post Your Comments:

(Date:6/14/2019)... ... June 14, 2019 , ... This past Saturday, volunteers from Bright Now! ... hosted the Parma Heights Day of Giving, where members of underserved communities were able ... nonprofits that partnered with the Smiles for Everyone Foundation. Some of these ...
(Date:6/13/2019)... ... ... Gynecology specializes in pelvic pain treatment for women. Pelvic pain can occur from a ... and complicated pelvic pain conditions including:, , Uterine fibroids , ... Adhesions (scar tissue) , Interstitial Cystitis , Pelvic inflammatory disease ...
(Date:6/13/2019)... SAN DIEGO (PRWEB) , ... June 13, 2019 ... ... 96-hour pain relief patch, announces their partnership with cannabis delivery company, Driven Deliveries, ... , Driven Deliveries, Inc., covers 93% of the population of California with ...
(Date:6/13/2019)... CHICAGO (PRWEB) , ... June 13, 2019 , ... In ... in schools across the United States, the collective impact movement Active Schools ... or are not, promoting childhood health and well-being. , The U.S. Department of ...
(Date:6/13/2019)... ... 13, 2019 , ... Many people with back pain that radiates down their ... is widely misunderstood and so are its treatments, according to Kaliq Chang, MD, double ... , “Sciatica is commonly used to describe nerve-like pain traveling down the legs, ...
Breaking Medicine News(10 mins):
(Date:6/18/2019)... BRENTWOOD, Tenn. (PRWEB) , ... June 18, 2019 ... ... a leader in emergency medicine and hospital medicine management services, are pleased to ... management company based in Longview, Texas. , LEMA’s 34 physicians and 9 ...
(Date:6/16/2019)... Mass. (PRWEB) , ... June 15, 2019 , ... ... Raynham, a stem cell clinic offering state-of-the-art treatment with cutting-edge technology, has opened. ... more details about the game-changing healing capabilities of regenerative medicine. , “Using ...
(Date:6/13/2019)... , ... June 13, 2019 , ... ... open its doors to a wellness center dedicated to realizing your optimal health, ... Plastic Surgery & Skin Aesthetics, BESANA Health & Wellness offers a range of ...
Breaking Medicine Technology:
Cached News: