New DNA chip method could improve cancer diagnosis

One of the biggest challenges in cancer treatment is choosing the right regimen for a given patient. Treatment strategies work differently for different tumors. In choosing effective treatments with minimal side effects, oncologists rely heavily on biopsy reports that diagnose the tumor type involved. However, even today, cancer diagnosis is done the old-fashioned way: by observing morphological changes in biopsies under the microscope. The method suffers from serious limitations because cancer cells that look similar under the microscope can follow different clinical courses and respond differently to therapy.

Now, in a new study reported in Friday's Science, a team of Whitehead-led researchers reports the first systematic and objective approach for identifying and classifying tumor types. This approach exploits the hot new technology of DNA microarrays--DNA chips that can analyze the activity of thousands of genes at a time--and could be used in the future to accurately diagnose cancer subtypes and also to predict clinical outcomes. Moving cancer diagnosis away from visually based systems to such molecular based systems is a major goal of the National Cancer Institute.

In the study, scientists used a DNA chip to examine gene activity in bone marrow samples from patients with two different types of acute leukemia--acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Then, using a computer algorithm, also developed at the Whitehead, they identified signature patterns that could distinguish the two types. When they cross-checked the diagnoses made by the chip against known differences in the two types of leukemia, they found that the chip method could automatically discover the distinction between AML and ALL without previous knowledge of these classes.

"These results demonstrate the feasibility of cancer diagnosis based solely on gene expression and suggest a general strategy for discovering new subtypes of cancer, indepen

Contact: Seema Kumar
Whitehead Institute for Biomedical Research

Page: 1 2 3

Related medicine news :

1. New fingerprint visualization method uses X-rays to reveal missing clues
2. A new method for early detection of disease outbreaks
3. New method to fix cleft palate shows promise in Mayo Clinic lab study
4. Colonoscopy still most effective colorectal cancer screening method
5. Colonoscopy most reliable method for detecting colon cancer
6. Stanford study finds new method improves chemotherapy survival in mice
7. New marrow transplant method developed at Stanford may eliminate fatal side effects
8. New sampling method to track HIV-risk behavior
9. Initiative yields effective methods for anthrax detection; RAMP and MIDI, Inc., methods approved
10. Interventional methods may increase the use of evidence-based practice
11. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students

Post Your Comments:

(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology:
Cached News: