HOME >> MEDICINE >> NEWS
New Drug Boosts The Power Of Traditional Cancer Therapies, UF Animal Studies Show

GAINESVILLE---A substance first identified in the bark of an African tree magnifies the tumor-cell killing power of radiation therapy by as much as 500 times in laboratory animals, University of Florida researchers reported today (11/23).

"We are always pursuing new avenues to enhance our conventional cancer therapies, radiation and chemotherapy," said Dietmar Siemann, a professor of radiation oncology in UF's College of Medicine. Siemann, his graduate student Lingyun Li, and pathologist Amyn Rojiani of the Moffitt Cancer Center in Tampa authored the paper in the November issue of the International Journal of Radiation Oncology, Biology, Physics.

"The results with combretastatin A-4 prodrug are very encouraging. We're able to achieve these effects by giving relatively low doses that produce no side effects in mice," Siemann said. Combretastatin A-4 prodrug, one of a new class of compounds that launch an indirect attack on tumors by interfering with their blood supply, is seen as a potentially effective therapy for solid tumors, which represent the vast majority of cancers.

Siemann's research was supported in part by a grant from OXiGENE Inc., the developer of the drug. Earlier this month, the Boston- and Sweden-based biopharmaceutical company announced it has begun Phase I clinical trials in human patients with advanced cancers to test the safety and maximum tolerated doses of combretastatin. Following successful Phase I trials, further clinical testing would be required to measure the drug's effectiveness, to determine dosages and to compare its tumor-destruction results with standard treatments. Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum, was identified a decade ago by George R. Pettit and his colleagues at Arizona State University. In collaboration with the National Cancer Institute and the Gray Laboratory in the United Kingdom, they have since demonstrated it can kill tumor cell
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
23-Nov-1998


Page: 1 2 3

Related medicine news :

1. Morning Coffee Boosts Blood Pressure, Stress Hormones All Day
2. Interleukin-2 Boosts Cancer Vaccine Effectiveness In Mice
3. Bi-Monthly Boosts Of Aspirin Benefit Heart
4. NIAID Stops AIDS Study Prematurely Because Drug Cocktail Boosts Survival
5. Powerful stem cells harnessed to search for cancer metastasis
6. Powerful burn-prevention video wins national award
7. Power nap prevents burnout; morning sleep perfects a skill
8. Power struggles within health service - as hospital workers shirk responsibility
9. Protein Power: Salt cloud concept shows promise for developing new drugs and foods faster, at lower cost
10. Less Toxic Bone Marrow Transplant Technique May Have More Powerful Anti-Cancer Effect
11. E-mail Is A Powerful Tool In Doctor-Patient Relationship

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Pekin, IL (PRWEB) , ... October 13, 2017 ... ... Foundation, which established the certification process to promote standards of excellence for the ... iaedp™ Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/11/2017)... FRISCO, Texas , Oct. 11, 2017 /PRNewswire/ ... healthcare services, has amplified its effort during National ... patients about hereditary cancer risks. ... Journal of Clinical Oncology calculated that more than ... to have inherited mutations in BRCA1 or BRCA2 and ...
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology:
Cached News: