HOME >> MEDICINE >> NEWS
New Drug For Recurrent Brain Tumors In Tests At UNC

CHAPEL HILL - Clinical trials are now underway at the University of North Carolina at Chapel Hill on a promising new drug in the fight against malignant and recurrent brain tumors that have so far proved very difficult to treat.

The tumors studied, glioblastoma multiformae (GBM) and anaplastic astrocytoma, originate in the brain. Of roughly 13,000 malignant brain tumors diagnosed in the United States each year, about 60 percent are GBM and about 20 percent are anaplastics, according to Dr. Matthew Ewend, assistant professor of neurosurgery and section chief of neuro-oncology at the UNC-CH School of Medicine.

"Average survival for patients with glioblastoma multiformae is about one year. It's very malignant and tends to come back at the same site," Ewend explains. "Surgery won't cure it, nor will radiation, although both are of benefit. Chemotherapy to date has had limited success."

Ewend, a member of the UNC Lineberger Comprehensive Cancer Center, says one study is a randomized, phase III clinical trial in which patients with GBM will receive either the new drug SU101 or procarbazine, a standard chemotherapy agent. All participants in this trial will be those whose tumors have returned after previous treatment, including surgery, radiation, and perhaps chemotherapy.

SU101, manufactured by Sugen in Redwood City, Calif., is thought to prevent tumor cell growth by blocking specific molecules on the surface of tumor cells. Laboratory research suggests that these "receptor sites," which attract a hormone-like substance called platelet-derived growth factor (PDGF), appear in increased numbers on tumor cells. Initial clinical studies in 80 patients have shown that nearly half have a positive reaction to the drug.

"It's been suggested that the cells over-express the PDGF receptor and they stimulate themselves to grow. It is as if they're pouring gas on their own fire," Ewend says. "By blocking or inhibiting that receptor, we might inhibit the cel
'"/>

Contact: Lynn Wooten
lwooten.est1@mail.unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
23-Mar-1999


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain tumor with dismal prognosis in infants can be cured in older children
6. Brain-scanning technologies need standards, according to Stanford researcher
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Brain synapse formation linked to proteins, Stanford study finds
9. Brain tumor treatment can vary greatly, according to new JAMA study
10. Brain region identified that controls collecting behavior
11. Brain imaging reveals new language circuits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ... February 13, 2019 , ... With Valentine’s Day tomorrow ... disease (STD) testing service, is sharing 7 tips to ensure ‘Safe Sex’: , ... you’re going to engage in safe sex. Having clear, open, and honest communication is ...
(Date:2/13/2019)... ... February 13, 2019 , ... Castle announced today that it has ... existing investors Y Combinator , First Round and F-Prime Capital ... Security, René Bonvanie, CMO at Palo Alto Networks, and Olivier Pomel, CEO at Datadog. ...
(Date:2/13/2019)... ... 13, 2019 , ... A Place at Home has received the ... The Employer of Choice Award is granted only to the top-ranking home care providers, ... firm for home care. A Place at Home is ranked among the best employers ...
(Date:2/13/2019)... MINOT, N.D. (PRWEB) , ... February 13, 2019 , ... ... its new Hybrid-Responsive™ website: https://www.dakotadental.net . , According to Douglas Bengson, owner of ... to get to know who we are and what we can do to improve ...
(Date:2/12/2019)... ... February 12, 2019 , ... Medical Device Risk Management, Prepare ... Feb. 19-20, 2019, Atlanta, GA , https://www.fdanews.com/mdriskmanagement , One week left ... on Jan. 22 , Risk management is just plain hard, complicated, conflicted, confusing. ...
Breaking Medicine News(10 mins):
(Date:2/16/2019)... ... 2019 , ... In observance of Gum Disease Awareness Month, ... to take their oral health seriously. With recent suggested links between gum disease ... pre-term birth, there is plenty to be concerned about along with tooth loss ...
(Date:2/16/2019)... and HERSTAL, Belgium (PRWEB) , ... February 15, ... ... positive data and observations from multiple studies and patient registries demonstrating the value ... American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), taking place in ...
(Date:2/14/2019)... (PRWEB) , ... February 14, 2019 , ... ... been designated as a UroLift® Center of Excellence. The designation recognizes that Dr. ... System and demonstrated a commitment to exemplary care for men suffering from symptoms ...
Breaking Medicine Technology:
Cached News: