New Math, High-Tech Imaging Solving Old Riddle: How Does The Brain Operate When...( ood-oxygen-level dependent (BOLD)fMRI...),Health

ood-oxygen-level dependent (BOLD) fMRI, it is based on the fact that magnetic properties of hemoglobin, the oxygen-carrying molecule in blood, change in brain areas that become active. That's because when hemoglobin is not carrying oxygen, it increases the strength of the magnetic field set up by MRI in that area of the body. In turn, this alters MRI signals released by molecules in there.

The researchers demonstrated the accuracy of their math by comparing normal animal brain activity to abnormal activity caused by decreased oxygen in the blood. The team lowered the amount of oxygen in animals for about 45 minutes, then recorded changes in MRI signals due to the decrease in the number of hemoglobin molecules carrying oxygen. The oxygen levels were then returned to normal levels and the signals again measured.

Other authors of the study include Scott M. Eleff, John A. Ulatowski, Aziz M. Ulug and Richard J. Traystman (Johns Hopkins), Joni M.E. Oja (Johns Hopkins and University of Kuopio; Kuopio, Finland) and Risto A. Kauppinen (University of Kuopio; Kuopio, Finland).

--JHMI--

Media Contact: Marc Kusinitz (410)955-8665 E-mail: mkusinit@welchlink.welch.jhu.edu

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Contact: Marc Kusinitz
mkusinit@welchlink.welch.jhu.edu
(410)955-8665
Johns Hopkins Medical Institutions
27-Feb-1998

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