HOME >> MEDICINE >> NEWS
New NCI grant will support Jefferson trial to study test to diagnose colorectal cancer spread

Researchers at Jefferson Medical College and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, buoyed by a new five-year, $5 million grant from the National Cancer Institute, are beginning a clinical trial to determine whether a simple test for the protein that causes traveler's diarrhea will help provide surgeons and oncologists with a more accurate picture of the extent of colorectal cancer in patients. The scientists hope the test will enable them to determine whether or not cancer has spread from the colon to the lymph nodes, and at the same time, result in improved diagnoses and more appropriate treatment.

The work, led by Scott Waldman, M.D., Ph.D., Samuel M.V. Hamilton Family Professor of Medicine and director of the Division of Clinical Pharmacology at Jefferson Medical College, may ultimately result in a blood test that could tell patients whether their colorectal cancer thought cured has returned.

The test looks for evidence of a protein, guanylyl cyclase C, or GCC, which is expressed only by intestinal cells and colorectal cancer cells. Most colorectal cancers originate in the cells that line the intestine - cells that normally make GCC. When the cells become cancerous, they continue to make GCC.

According to Dr. Waldman, knowing the extent of disease is crucial to managing patients with colorectal cancer. Patients typically undergo surgery to remove the cancer and the nearby lymph nodes, which are the first place cancer usually spreads. After surgery, a pathologist examines lymph node tissue for cancer cells. If none are found, the patient is "staged" as having cancer confined to the bowel. But if cancer is found in the lymph nodes, the patient's prognosis and management changes.

"It's apparent that the further the progression of disease, the worse the prognosis of the patient," he says. If the disease is found outside of the intestine, for example, most patients are given chemotherapy.

But such a
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
20-Jun-2002


Page: 1 2 3 4

Related medicine news :

1. UNH launches 2nd spinout company with NIH grants
2. Mailman School of Public Health receives Manhattan Tobacco Cessation Center grant
3. $4 million grant boosts University of Michigan campaign for a new childrens hospital
4. Disease testing for immigrants: Discrimination disguised as public health policy
5. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
6. NYU Child Study Center receives grant from the American Red Cross September 11 recovery program
7. US FDA grants full approval to DOXIL(R) following submission of phase III data
8. Dartmouth awarded $21.8 million NSF grant
9. ASGE announces grant recipients in annual research awards program
10. Insulin resistance intervention after stroke focus of $33 million grant
11. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
Breaking Medicine Technology:
Cached News: