HOME >> MEDICINE >> NEWS
New NCI grant will support Jefferson trial to study test to diagnose colorectal cancer spread

system is flawed because most pathologists examine only a thin slice of lymph node tissue, Dr. Waldman says, potentially missing a cancer. In addition, such a test lacks sensitivity, relying on a pathologist's eye to see colon cancer cells in a field of cells on a slide.

"There's clearly a problem with that system because about 20 percent of patients thought to have disease confined to the bowel show up with recurrent disease and ultimately die of the returning disease," he says. "There's thought to be micrometastases that have escaped histopathological detection."

Dr. Waldman thinks there is a better way. He uses a two-pronged approach: a powerful amplification technique called RT-PCR analysis to magnify the presence of cancer cells compared to normal cells and couples it with GCC, which he hopes will be a very specific marker for cancer. "Then you can take a lymph node and use the amplification technique to amplify the signal for cancer," he explains.

GCC appears to be very specific to colon cancer cells outside the intestine, and is only expressed in metastatic colon cancer cells that have spread there. By combining the marker with the amplification technique, which can detect one cancer cell in 10 million cells, researchers may have a very specific and sensitive way to detect metastatic colon cancer cells in the lymph nodes of patients undergoing colorectal cancer staging, he says.

"We hope to use this new molecular technique to improve the accuracy of colorectal cancer staging so that more people can receive chemotherapy and can benefit from it," he says.

The trial, for which recruitment has already begun, is looking at approximately 2000 patients at five centers: Jefferson, Fox Chase Cancer Center in Philadelphia, the University of Florida in Gainesville, McGill University in Montreal and a community hospital, Conemaugh Memorial Medical Center in Johnstown, Pa.

The trial will examine RT-PCR-GCC analysis as a method to determine
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
20-Jun-2002


Page: 1 2 3 4

Related medicine news :

1. UNH launches 2nd spinout company with NIH grants
2. Mailman School of Public Health receives Manhattan Tobacco Cessation Center grant
3. $4 million grant boosts University of Michigan campaign for a new childrens hospital
4. Disease testing for immigrants: Discrimination disguised as public health policy
5. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
6. NYU Child Study Center receives grant from the American Red Cross September 11 recovery program
7. US FDA grants full approval to DOXIL(R) following submission of phase III data
8. Dartmouth awarded $21.8 million NSF grant
9. ASGE announces grant recipients in annual research awards program
10. Insulin resistance intervention after stroke focus of $33 million grant
11. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology:
Cached News: