HOME >> MEDICINE >> NEWS
New Protease Inhibitor Could Thwart AIDS Resistance To Current Drugs

Researchers have developed a new protease inhibitor effective against mutating strains of the human AIDS virus that are resistant to current drugs, according to a just-released report in the peer-reviewed Journal of the American Chemical Society.

The paper will be published on the web on Feb. 4 and will be in the journal's Feb. 17 print edition. The American Chemical Society is the world's largest scientific society.

Most AIDS drugs disable the human immunodeficiency virus (HIV) by latching onto an enzyme, such as a protease, that the virus needs to multiply. However, HIV quickly mutates and becomes resistant to individual inhibitors within weeks.

The most successful treatment to date tries to overwhelm HIV with two or three of these drugs simultaneously in a so-called "combination therapy," but even this approach eventually loses effectiveness.

Researchers at The Scripps Research Institute in La Jolla, Calif. think they now know how HIV adapts so readily to the current treatments. Over time, HIV proteases apparently change structure so that the inhibitors can no longer bind tightly. "We have studied the mutation pattern of HIV protease from patients who take the existing drugs and found that the enzyme often rejects the drug by reducing the size of the drug binding site," says Scripps chemist Chi-Huey Wong, Ph.D.

The scientists then looked at the corresponding binding site on current HIV protease inhibitors and found that most of them have large chemical structures that interact with the constricted areas in drug-resistant proteases. So they redesigned the drugs, giving them a smaller chemical group at the critical binding site. In laboratory tests, the new class of inhibitors was effective against both HIV protease and its drug-resistant mutants. "More importantly," adds Wong, "no resistant mutants were detected in cell culture after one year the new drug may last longer as the chance for development of drug resistance is lower
'"/>

Contact: Nancy Blount
n_blount@acs.org
202-872-4440
American Chemical Society
3-Feb-1999


Page: 1 2

Related medicine news :

1. Protease inhibitor could help prevent alzheimers
2. HIV Patients Treated With Protease Inhibitors Are More Likely To Engage In Risky Sex, Emory Researchers Report
3. Only Eight Percent Of San Francisco HIV-Positive Urban Poor Receive Protease Inhibitors
4. Answers To Access, Adherence And Tolerance Of Protease Inhibitors
5. Declining National Rates Of HIV-Related Deaths And Illnesses Due To Combination Antiretroviral Therapy With Protease Inhibitors
6. Inhibitors prevent aggresome formation associated with some forms of ALS
7. Acetylcholinesterase Inhibitors May Be Another Piece In Alzheimers Jigsaw
8. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
9. ACE-Inhibitors Score High In Reducing Heart Attack Deaths
10. Could skin cells become brain cells?
11. Could autoantibodies predict future disease in healthy people?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: