New Protease Inhibitor Could Thwart AIDS Resistance To Current Drugs

Researchers have developed a new protease inhibitor effective against mutating strains of the human AIDS virus that are resistant to current drugs, according to a just-released report in the peer-reviewed Journal of the American Chemical Society.

The paper will be published on the web on Feb. 4 and will be in the journal's Feb. 17 print edition. The American Chemical Society is the world's largest scientific society.

Most AIDS drugs disable the human immunodeficiency virus (HIV) by latching onto an enzyme, such as a protease, that the virus needs to multiply. However, HIV quickly mutates and becomes resistant to individual inhibitors within weeks.

The most successful treatment to date tries to overwhelm HIV with two or three of these drugs simultaneously in a so-called "combination therapy," but even this approach eventually loses effectiveness.

Researchers at The Scripps Research Institute in La Jolla, Calif. think they now know how HIV adapts so readily to the current treatments. Over time, HIV proteases apparently change structure so that the inhibitors can no longer bind tightly. "We have studied the mutation pattern of HIV protease from patients who take the existing drugs and found that the enzyme often rejects the drug by reducing the size of the drug binding site," says Scripps chemist Chi-Huey Wong, Ph.D.

The scientists then looked at the corresponding binding site on current HIV protease inhibitors and found that most of them have large chemical structures that interact with the constricted areas in drug-resistant proteases. So they redesigned the drugs, giving them a smaller chemical group at the critical binding site. In laboratory tests, the new class of inhibitors was effective against both HIV protease and its drug-resistant mutants. "More importantly," adds Wong, "no resistant mutants were detected in cell culture after one year the new drug may last longer as the chance for development of drug resistance is lower

Contact: Nancy Blount
American Chemical Society

Page: 1 2

Related medicine news :

1. Protease inhibitor could help prevent alzheimers
2. HIV Patients Treated With Protease Inhibitors Are More Likely To Engage In Risky Sex, Emory Researchers Report
3. Only Eight Percent Of San Francisco HIV-Positive Urban Poor Receive Protease Inhibitors
4. Answers To Access, Adherence And Tolerance Of Protease Inhibitors
5. Declining National Rates Of HIV-Related Deaths And Illnesses Due To Combination Antiretroviral Therapy With Protease Inhibitors
6. Inhibitors prevent aggresome formation associated with some forms of ALS
7. Acetylcholinesterase Inhibitors May Be Another Piece In Alzheimers Jigsaw
8. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
9. ACE-Inhibitors Score High In Reducing Heart Attack Deaths
10. Could skin cells become brain cells?
11. Could autoantibodies predict future disease in healthy people?

Post Your Comments:

(Date:8/31/2018)... , ... August 31, 2018 , ... ... | 2018" list. , This list includes independent community hospitals as well as ... others care for small communities outside of large cities. The hospitals continue to ...
(Date:8/31/2018)... ... 2018 , ... Kessler Foundation, a major center for rehabilitation ... In the MRI Simulator, the individual experiences the conditions of an actual magnetic ... research participants become accustomed to the sights and sounds of the actual scan, ...
(Date:8/31/2018)... ... August 31, 2018 , ... The ... Heart Association (AHA) to be responsive for procurement purposes. , A 100 million ... now reap the benefits. Companies like Pacific Medical Training are already offering VA ...
(Date:8/31/2018)... TIRANA, Albania (PRWEB) , ... August 31, 2018 ... ... announces research results based on the impact of a biofield energy treated nutraceutical ... preclinical research assessed biomarkers for immune function and blood, as well as, inflammation. ...
(Date:8/31/2018)... ... 2018 , ... Saturday, September 1st, 2018, Team Fastrax™ will perform their fan ... opener game. At 7pm, the Cyclones will kick off against the South Dakota State ... Fastrax™ will jump in with their majestic 2,000 sq. ft. American Flag, red white ...
Breaking Medicine News(10 mins):
(Date:9/12/2018)... COLUMBUS, Ohio (PRWEB) , ... September 13, 2018 , ... ... fastest growing companies, as well as Columbus Business First's Fast 50 list of central ... national list with a 3-year growth rate of 81 percent. It is the only ...
(Date:9/7/2018)... , ... September 07, 2018 , ... ... her new book “Diagnosis: Cancer”: a gripping narrative that shows the author’s experience ... in Africa. , Author Uonelli writes an eventful life that revolves around a ...
(Date:9/3/2018)... ... September 03, 2018 , ... According to ACGME, the state ... residents and 200 fellows for the 2018-2019 academic year. The 64 specialty programs ... institutions such as McLeod Health, MUSC Health, Tidelands Health and Tenet Healthcare will ...
Breaking Medicine Technology:
Cached News: