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New TB vaccine shows promise in HIV infection

for Hepatitis B. Parallel studies were also conducted on HIV- negative subjects.

"The multiple-dose course of the inactivated vaccine boosted immunity against TB both in those with HIV and those without TB," von Reyn said. "The vaccine was also safe and did not adversely affect the patients' underlying HIV infection."

The study served as the basis for a large-scale trial Dartmouth researchers have been conducting since 2001 in Dar es Salaam, Tanzania with Muhimbili Hospital Medical Center. The five-year $3 million NIH funded study is the only efficacy trial of a new TB vaccine currently under way in the world. The Tanzania trial will enroll more than 2000 HIV-infected patients to determine if the boosted immunity detected in the Finnish study actually reduces the risk of tuberculosis among HIV infected people in Tanzania at high risk of the disease.


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Contact: Andy Nordhoff
DMS.Communications@dartmouth.edu
603-650-1492
Dartmouth Medical School
6-Nov-2003


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