The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> MEDICINE >> NEWS
New Vaccine Being Tested In Prostate Cancer Patients

Chemists at the Sloan-Kettering Institute for Cancer Research have created a novel vaccine they hope will thwart prostate cancer. Now in early human trials, the vaccine is the first made synthetically to target abundant, but elusive, carbohydrates on the surface of tumor cells.

The development will be outlined in the November 20 Web edition of the Journal of the American Chemical Society, published by the American Chemical Society, the world's largest scientific society. It is scheduled to appear in the print version of the peer-reviewed journal on November 25.

Using vaccines to stimulate an immune response against cancer typically focuses on proteins, which are relatively easy to make but often arelodged within cells and not easily accessible to antibodies. Most of the good targets, or antigens, on a cancer cell's surface are not proteins, however. Instead they are small, difficult to synthesize carbohydrates whose immunogenicity is not well-understood.

"Normally the carbohydrates are much more complex in normal cells. In cancer cells they're often very different," says lead author and Sloan Kettering Institute for Cancer Research chemist Scott D. Kuduk, Ph.D. The difference should enable scientists to exclusively target cancer.

Kuduk, who works in the lab of Kettering Chair and Director of Bioorganic Chemistry, Samuel J. Danishefsky, Ph.D., says their group successfully synthesized two key tumor carbohydrate antigens -- called TF and Tn. They then clustered the antigens as they occur naturally and attached them to proteins which help produce an immune response. "Through chemistry, we were able to make substantial quantities of the material that allowed us to then do the testing," adds Kuduk. In mice, the Tn-protein complex was especially effective at triggering antibody production.

"It's a wonderful antigen for prostate cancer because Tn is one of the main antigens on prostate cancer cells," according to co-author and Sloan Ketteri
'"/>

Contact: Randy Atkins
r_atkins@acs.org
202-872-4097
American Chemical Society
20-Nov-1998


Page: 1 2

Related medicine news :

1. Vaccine against childhood pneumonia shows promise
2. Vaccine may complement conventional treatment for chronic leukaemia
3. Vaccine preparedness, or not
4. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
5. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
6. Vaccine nips breast cancer in the bud
7. Vaccine shows promise for kidney cancer
8. Vaccine development against influenza A (h5n1) virus should be made a priority
9. Vaccines against fatal African cattle fever
10. Vaccine development sparks debate on changes to cervical cancer screening guidelines
11. Vaccine shortage study exposes nations patchwork system

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Vaccine Being Tested Prostate Cancer Patients

(Date:11/24/2009).../PRNewswire/--Whiletheholidayseasonoftenbringsfami...rcanbedifficultforthosegrievingthedeathofalovedone...families.Theholidayseasoncanbringadditionalchallen...lace,ACenterforGrievingChildren,AdolescentsandThei...tiontohavingavarietyofprintandonlineresourcesavail...
(Date:11/24/2009)...24/PRNewswire-USNewswire/--Dr.NelsonEscobar,aphysi...cipientoftheJamesBradyAward.Theawardwaspresentedto...gtheirannualconferenceonOctober30,2009. ,, Acco...inrecognitionofhisexpertiseinaddressingthecomplexn...atmentandexceptionalcareofhispatientsandtheirfamil...
(Date:11/24/2009).../PRNewswire/--TheUnionLaborLifeInsuranceCompany("U...SP(®),()thenation,slargestvisionbenefitsandse...uctstounions,uniontrustfunds,unionemployersandthei...ringservicesincludingcomprehensiveeyeexams,broadse...ortantqualityeyecareis,"statedBruceSmith,NationalS...
(Date:11/24/2009)...RNewswire-FirstCall/--CenteneCorporation(NYSE: CNC...idhasselectedCenteneasoneoftwoCoordinatedCareOrgan...cessNetwork(MississippiCAN),acoordinatedcareprogra...ingwiththeDivisiontoexecuteacontractinwhichthecomp...gnoliaHealthPlan(Magnolia). ,, BasedinJackson,M...
(Date:11/24/2009)...hoking hazard, are too loud, or contain dangerous ...y News) -- As the holiday shopping season begins, ...still being sold in stores across the United State...Trouble in Toyland report, released Tuesday by th... The report focuses on toys that pose a choking ha...
Breaking Medicine News(10 mins):Health News:Highmark Caring Place Resources Help Children and Families Who Are Grieving During the Holidays 2Health News:Marianjoy Medical Group Physician Receives James Brady Award 2Health News:Union Labor Life & VSP Vision Care Align to Offer Vision Insurance Products 2Health News:Centene Corporation Receives Notification of Intent to Contract From the State of Mississippi 2Health News:Dangerous Toys Still on Store Shelves, Report Finds 2Health News:Dangerous Toys Still on Store Shelves, Report Finds 3
(Date:11/24/2009)... ,, WHAT:RomHoubens,aBelgianmanthoughttohavebee...lyfullyconsciousandawakeduringthattimeandwasthesub...asfeaturedinthesegmenttoillustratehowpeoplewithLoc...tion. ,, WHEN:GoodMorningAmerica-- Tuesday,Nove... ,, WHO:RomHoubenswasanengineeringstudentin198...
(Date:11/24/2009)...e-FirstCall/--Vermillion,Inc.(VRML)(PinkSheets:VRM...andDisclosureStatementtoday,November24,2009,withth...re.AhearingtoconsiderapprovaloftheDisclosureStatem...aringontheconfirmationofthePlanscheduledforJanuary...imsinfull.ThePlanisexpected,ifapproved,toallowhold...
(Date:11/24/2009)...-Inadditiontofamily,friendsandhealth,cancersurvivo...sgivinggratitudelist. ,, "Theyheardthefactsandm...day,sverdictstotaling$103millionindamagesagainstWy...ennationwidewhohavesuedWyethandPfizerpharmaceutica...o.Wisneskiandtheothervictimsofhormonetherapyhaveal...
Breaking Medicine Technology:DynaVox EyeMax Featured in Good Morning America Segment About Man Thought To Be in Coma for 23 Years 2Vermillion Files Plan of Reorganization 2Vermillion Files Plan of Reorganization 3Maryland Woman Thankful for Wyeth Verdicts 2Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 1Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 2Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 3Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 4Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 5Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 6Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 7Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 8Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 9Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 10Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 11Reportlinker Adds Bariatric 28Obesity 29 Surgical Devices Report 56411 12Image Sensors 2009 Offers Promotional Discount on Machine Vision and Wireless Power Summits 56410 1Image Sensors 2009 Offers Promotional Discount on Machine Vision and Wireless Power Summits 56410 2Image Sensors 2009 Offers Promotional Discount on Machine Vision and Wireless Power Summits 56410 3AARP Delivers Health Care Reform Message in a Bottle to Cong Hare 56407 1
Other News:
... (May 4, 2004) Long-term use of AndroGel (testost...ith hypogonadism, a condition sometimes referred t...blished today in the May issue of the Journal of C...e first to examine safety and efficacy of testoste...
... Children with asthma whose parents smoke at home ...ar long than children of non-smokers, a new study ...ildren with asthma, about 13 percent of parents of...ond-hand smoke is known to trigger asthma attacks ...
...stolic blood pressure levels for children and teen...ng to a new study supported by the National Heart,...tional Institutes of Health. The study links part...lence of overweight and obesity.... The study--"Tr...
...can-Americans who live in the inner city have a hi...ich can lead to additional health problems, accord... of Medicine and the Regenstrief Institute, Inc. ....n African-Americans, Douglas Miller, M.D., profess...
health news:Testosterone gel (AndroGel(R)) study first to show long-term benefits and safety 2health news:Testosterone gel (AndroGel(R)) study first to show long-term benefits and safety 3health news:Kids' year-round asthma symptoms triggered by parent's second-hand smoke 2health news:Kids' year-round asthma symptoms triggered by parent's second-hand smoke 3health news:Average blood pressure levels on rise among American children/teenagers 2health news:Average blood pressure levels on rise among American children/teenagers 3health news:Average blood pressure levels on rise among American children/teenagers 4health news:Depressive symptoms in middle-aged inner-city African-Americans higher than expected 2
... the risk of recurrent depression and increase the...patients with diabetes, according to a study in th... of the JAMA/Archives journals.......One of every ...epression, according to background information in ...
...ed $23 billion yearly to the alcohol industry, mor...es for alcohol, according to an article in the May...cine, one of the JAMA/Archives journals.......In 1...84 billion, more than cancer ($107 billion) or obe...
...y increases the risk of death and hospitalization ... disease (COPD).......These findings appear in the...y and Critical Care Medicine, published by the Ame...of the University of Kentucky Medical Center, and ...
... as 88 percent for common interventional radiology... study shows......."The study included 291 patient...n or catheter placement procedures," said Brian Lu...Medical Center. ......"These patients undergo dia...
health news:Antidepressant medication may prevent recurring depression in diabetics 2health news:Underage drinkers account for about 17 percent of consumer expenditures for alcohol 2health news:Rapid lung function decline raises risk of death and hospitalization 2health news:Low radiation dose still means successful interventional procedures, a new study shows 2