New Vaccine Provides Protection From HIV In Monkeys

ATLANTA -- AIDS researchers at Yerkes Regional Primate Research Center have created a DNA vaccine that protects monkeys against a formidable challenge HIV virus. Achieving protection with this vaccine, made with harmless components from a SHIV -- a blend of parts from HIV and SIV (simian or monkey immunodeficiency virus) -- marks a significant and promising step toward the development of an effective AIDS vaccine. The study results are reported in the May issue of Nature Medicine by Dr. Harriet Robinson, Chief of Microbiology and Immunology at Yerkes Primate Center.

In a three-year study, Dr. Robinson compared combinations of three different vaccine approaches and two different delivery methods for administering them. The most effective vaccination involved two steps: first "priming" the immune system with a DNA vaccine, which consisted of genes taken from a SHIV. The genes express specific SHIV proteins that help the body produce an initial immune response. This was followed 46 and 66 weeks later with "booster" immunizations with the same SHIV DNA inserted into a pox virus. The pox virus deftly invades the host's cells, expressing very high levels of the useful SHIV proteins. However, once in the cells, the virus itself does not replicate. Thus it poses no risk of unwanted dissemination in the vaccinated individual.

Dr. Robinson also tested two different ways of introducing the DNA vaccine. Innoculation through the skin (intradermal) proved more effective in containing viral challenges than did administration with a "gene gun," which bombards cells with DNA-coated gold beads.

Dr. Robinson's vaccine was successful in containing the virus over a 62-week period, during which a series of three SHIV challenge infections were administered. The containment was remarkably effective, preventing detectable levels of virus in blood at all times post-challenge -- in contrast to unvaccinated animals, which had viral loads of up to one billion.

Contact: Kate Egan
Emory University Health Sciences Center

Page: 1 2 3 4

Related medicine news :

1. Vaccine against childhood pneumonia shows promise
2. Vaccine may complement conventional treatment for chronic leukaemia
3. Vaccine preparedness, or not
4. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
5. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
6. Vaccine nips breast cancer in the bud
7. Vaccine shows promise for kidney cancer
8. Vaccine development against influenza A (h5n1) virus should be made a priority
9. Vaccines against fatal African cattle fever
10. Vaccine development sparks debate on changes to cervical cancer screening guidelines
11. Vaccine shortage study exposes nations patchwork system

Post Your Comments:

(Date:9/1/2020)... , ... September 01, 2020 , ... ... new practice in Glendale. While the office will be the first to ... augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons at Allegheny ... from Carnegie Mellon University (CMU) to develop a new heart monitoring device designed ... heart surgery. , The AGH/CMU team was recently awarded a “Trailblazer” grant from ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic ... announced today the launch of its integrated, HIPAA compliant, telehealth solution, available to ... practice in under 90 seconds. , According to the U.S. Department of ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back ... donating 10 percent of each hotel room booked with a special new rate code ... Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room ...
(Date:8/28/2020)... ... 2020 , ... WHAT , Hespiro™ is a new type ... including COVID-19, while reducing the need for scarce mechanical ventilators. It not only ... scrubs it free of carbon dioxide in a completely closed “rebreather” system, important ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... AseptiScope, a privately funded San ... of the Year by MedTech Outlook. , “AseptiScope is pleased to receive ... time, clinicians who wear gloves on their hands, goggles on their eyes, covers on ...
(Date:8/26/2020)... , ... August 26, 2020 , ... As the U.S. ... the daily routine for preventing the Coronavirus. Wear a mask, keep your distance, wash ... advocate Dr. Denis Burkitt said it best in 1977, “How much better it is ...
(Date:8/26/2020)... SAN DIEGO (PRWEB) , ... August 26, 2020 ... ... services, announced today the appointment of Claude E. Hooton as President and Chief ... the role of Executive Chairman of the company’s Board of Managers. , ...
Breaking Medicine Technology:
Cached News: