HOME >> MEDICINE >> NEWS
New anti-angiogenic proteins discovered

Scientists at UCLA and Human Genome Sciences report discovery of two human proteins, METH-1 and METH-2, that inhibit blood vessel formation

More potent than endostatin, with potential for treating a range of cancer tumors

A team of scientists working at UCLA and Human Genome Sciences (NASDAQ: HGSI) discovered two human proteins that inhibit the formation of new blood vessels and have potential for treating cancer through suppression of tumor growth.

The two proteins, named METH-1 and METH-2, were shown to be much more active than endostatin in preventing blood vessel formation and may have applications in creating treatments for a broad range of tumor types.

The discovery of these two proteins and their anti-angiogenic activity is described in the August 13, 1999 issue of Journal of Biological Chemistry. The paper may be accessed at http://www.jbc.org .

The team, led by UCLA molecular biologist Luisa Iruela-Arispe, found that both METH-1 and METH-2 inhibited blood vessel formation in two standard biological model systems, the cornea pocket model and the chorioallontoic membrane model.

The ability of METH-1 and METH-2 to inhibit new blood vessel formation in the cornea pocket model was compared to that of both endostatin and thrombospondin, two other human proteins. The study showed that METH-1 was most potent in inhibiting blood vessel growth, followed by thrombospondin and endostatin.

A solid tumor cannot grow beyond the size of a pinhead unless it has an independent blood supply to deliver the oxygen and nutrients that the malignancy needs to advance and spread. To feed itself, a tumor develops its own blood supply, a process called angiogenesis. Researchers hope anti-angiogenic drugs can interrupt that process, thereby cutting off the blood supply to the tumor and, hopefully, killing it.
'"/>

Contact: Kate de Santis
kate_de_santis@hgsi.com
301-251-6003
Human Genome Sciences, Inc.
5-Aug-1999


Page: 1 2 3 4 5

Related medicine news :

1. Brain synapse formation linked to proteins, Stanford study finds
2. Scientists discover enzyme crucial to the transportation of proteins within cells
3. Uncoupling proteins in human heart
4. Lab studies show two proteins prevented progressive nerve cell loss in Parkinsons disease
5. Unexpected similarities between raindrops and proteins
6. Self-assembling proteins could help repair human tissue
7. New findings on nerve cell proteins show promise for reducing disability
8. C-reactive proteins do not predict early osteoarthritis
9. Two proteins may help prevent Alzheimers brain plaques
10. Cancers love-hate relationship with proteins offers new treatment window
11. Studies show Tim-3 proteins key to immune responses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
Breaking Medicine Technology:
Cached News: