HOME >> MEDICINE >> NEWS
New approach supercharges immunotherapy

By tripping two parallel "on switches" at once, instead of the customary single switch, physicians at the University of Chicago Medical Center may at last have found a way to bring the full power of the immune system into play against cancer. Early results from the first clinical trial of this approach will be presented December 5th at the American Society of Hematologists meeting in Miami Beach, Florida.

This phase-1 clinical trial -- designed not to assess effectiveness but to determine the optimal dose and measure toxicity -- involved patients with advanced or recurrent lymphoma who had not responded to prior chemotherapy. Although patients in phase-1 studies like this rarely have a lasting recovery, several of those enrolled in this trial have experienced noteworthy anti-tumor effects.

"When you consider that none of these patients had responded to any other therapy, you can begin to understand our enthusiasm," said David Liebowitz, M.D., Ph.D., director of stem-cell transplantation at the University of Chicago and principal investigator of the study. "Although this is a complex and difficult treatment regimen, all the early signs suggest that it can be a uniquely effective one."

The treatment is based on recent recognition of the importance of "co-stimulation" in triggering an immune response. Previous efforts to activate the immune system have relied on stimulation of a single signaling system, the T-cell receptor for antigen, known as CD3, a cell-surface molecule that recognizes foreign tissue.

Nearly ten years ago, however, Chicago researchers Craig Thompson and Jeffrey Bluestone and others discovered that the immune system often requires two parallel lines of communication -- through both CD3 and a second receptor, known as CD28 -- before girding for battle. Stimulation of both CD3 and CD28 triggers an aggressive immune response; tweaking only CD3 produces little or no respo
'"/>

Contact: John Easton
jeaston@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
5-Dec-1998


Page: 1 2 3

Related medicine news :

1. OHSU scientists develop MRI approach to improve breast cancer detection
2. Trial reveals safer and simpler approach to treating children with cystic fibrosis
3. Services for children: Training needed to tackle complexity of new labours joined-up approach
4. Government approach to cutting hospital stays may be misleading
5. Is the 3 by 5 initiative the best approach to tackling the HIV pandemic?
6. Animal study suggests safer immunization approach to Alzheimers
7. Worldwide approach tackles kidney disease
8. Texas Childrens Hospital specialists say proactive approach best defense against flu season
9. Endoscopic approach best for repairing bone defect between brain, nasal cavity
10. University of Pittsburgh approach has lung recipients taking far fewer drugs
11. Tissue involved in brain development may offer new approach to stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 15, 2018 , ... ... of support thanks to a unique collaboration that puts vital health education resources ... Plan (Blue Shield of California Promise Health Plan effective 1/1/19), an affiliate of ...
(Date:11/15/2018)... ... November 15, 2018 , ... The National Cancer Institute estimates that 1.7 million ... primary risk factor for cancer and we typically associate the disease with old age, ... And with aggressive treatment and advanced therapies, increasing numbers of these patients survive their ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... ... latest version of its paperless, web-based eForms solution for hospitals . This ... enables users to launch eForms directly from any of these systems, have patients ...
(Date:11/15/2018)... ... November 15, 2018 , ... ... designated as a UroLift® Center of Excellence. The designation recognizes that Dr. Dehner ... and demonstrated a commitment to exemplary care for men suffering from symptoms associated ...
(Date:11/15/2018)... DELRAY BEACH, Fla. (PRWEB) , ... November 15, 2018 , ... ... Windham, NH and clinical educator for Specialty MED Training will take the ... Vegas, NV happening December 13-15, 2019. Dr. Vuich is leading a CME workshop hosted ...
Breaking Medicine News(10 mins):
(Date:11/16/2018)... ... ... Privately operated aerial firefighting companies quickly went into a rapid attack mode on the ... Fire, in Butte County, and the Woolsey and Hill fires in Ventura and Los ... All are still mostly uncontained. , “The successful first response by fixed wing ...
(Date:11/16/2018)... , ... November 16, 2018 , ... ... and innovative Dry Shampoo Collection that quickly refreshes and restores hair between washes. ... collection is comprised of three different products, including an instant drying foam that ...
(Date:11/16/2018)... ... November 16, 2018 , ... Strategic Radiology welcomes ... presence for the nationwide coalition of independent practices. , NVRA is based in ... County. The 13-radiologist subspecialized practice is a member of the Connecticut Imaging Alliance, ...
Breaking Medicine Technology:
Cached News: