HOME >> MEDICINE >> NEWS
New approach supercharges immunotherapy

nse.

"This discovery addresses the basic question facing cancer immunotherapy," said Liebowitz: "Why are the T cells that should attack tumors content to sit idly by? Previous efforts to jump start an immune response have not been able effectively to reverse the immune tolerance that develops between a patient's T cells and their cancer."

But by growing billions of a patient's T cells in the laboratory, away from tumor cells and under constant co-stimulation with CD3 and CD28, Liebowitz's team has been able to reactivate the immune response, returning a population of aggressive, "motivated" cells to seek out and attack cancerous cells.

"Co-stimulation gives us a completely different population of T cells," said Liebowitz. Prior attempts have produced large numbers of cytotoxic T cells, which are the end product of an immune response. Growth in the presence of CD3 and CD28, however, produces primarily T-helper cells, so called because they coordinate the actions of the entire immune system."

This is the only system currently in use that favors the growth of T-helper cells over cytotoxic cells.

A few weeks after receiving their new, improved T-helper cells, some patients have experienced fevers and lethargy while their T-cell counts continue to rise. Over the following weeks and months, much too slowly to be a late response to prior chemotherapy, their tumors get smaller and in some cases have disappeared.

"We know we are affecting the immune response with this therapy because the toxicities we have seen after reinfusion look exactly like autoimmune disorders," (in which an over-aggressive immune system attacks its host) said Liebowitz.

Although the side effects of reinfusing the rejuvenated T cells appear to be limited, the entire treatment protocol is quite rigorous. Treatment involves collecting and storing stem cells from the patient's blood, administering high-dose c
'"/>

Contact: John Easton
jeaston@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
5-Dec-1998


Page: 1 2 3

Related medicine news :

1. OHSU scientists develop MRI approach to improve breast cancer detection
2. Trial reveals safer and simpler approach to treating children with cystic fibrosis
3. Services for children: Training needed to tackle complexity of new labours joined-up approach
4. Government approach to cutting hospital stays may be misleading
5. Is the 3 by 5 initiative the best approach to tackling the HIV pandemic?
6. Animal study suggests safer immunization approach to Alzheimers
7. Worldwide approach tackles kidney disease
8. Texas Childrens Hospital specialists say proactive approach best defense against flu season
9. Endoscopic approach best for repairing bone defect between brain, nasal cavity
10. University of Pittsburgh approach has lung recipients taking far fewer drugs
11. Tissue involved in brain development may offer new approach to stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... February 19, 2019 , ... ... provider of advanced delivery technologies and development solutions for drugs, biologics and ... Biologics, will present at the annual US Bioassay Conference of the BioPharmaceutical ...
(Date:2/19/2019)... ... February 19, 2019 , ... Tap water issues in ... The Villages FL proudly serving over 3,500 satisfied customers. I’m looking forward to ... Jacksonville area selling and installing our popular Water Filtration Systems," says Bob Novak, ...
(Date:2/19/2019)... (PRWEB) , ... February 19, 2019 , ... ... with Clover Creek Cultivation LLC , a newly-licensed cannabis cultivation and manufacturing ... hydrocarbon and ethanol extraction, distillation, and ISO-7 product formulation, while Clover Creek is ...
(Date:2/19/2019)... ... February 19, 2019 , ... The California Dental Association is ... loan refinancing as a new member benefit. , Student loan debt is ... debt for all indebted graduates in the class of 2018 for public and ...
(Date:2/19/2019)... ... 2019 , ... ClearHealth Quality Institute (CHQI) has identified Emily ... Recognized Consultants. The CHQI Recognized Consultant Program trains third-parties to assist organizations, such ... Ms. Wein and Mr. Einhorn are part of Foley’s Telemedicine & Digital Health ...
Breaking Medicine News(10 mins):
(Date:2/19/2019)... ... February 19, 2019 , ... ... wellness industry. The rapid growth of this sector is expected to reach $11.6 ... one of the major leaders in this space. The company makes best in ...
(Date:2/19/2019)... ... 18, 2019 , ... Shady Grove Fertility invites information seekers ... egg freezing, and much more to attend the second annual Canadian Fertility Show, ... Joseph Doyle, M.D. on February 23, 2019 from 9:30 AM to 5 ...
(Date:2/16/2019)... ... February 15, 2019 , ... ... Recognition Program (MNSHARP) award for safety excellence. Commissioner Kristin Batson, Department of Labor ... award. , Safety is more than just a set of rules for AP; ...
Breaking Medicine Technology:
Cached News: