New approach to post-transplant lymphoma shows promise

COLUMBUS, Ohio - Scientists may be making significant headway in treating one of the most difficult and often fatal complications of organ transplant, PTLD, or post-transplant lymphoproliferative disorder.

PTLD is a form of lymphoma, or cancer of the glands of the lymph system, associated with the presence of the Epstein-Barr virus (EBV). Normally, EBV itself is not threatening - scientists say 90-95 percent of us carry it in our systems all the time. But it poses special problems for transplant patients because the drugs they have to take to keep their body from rejecting new organs weaken the immune system and create the perfect environment for the virus to spring into action.

Kidney transplants are among the most common transplants in the United States, with more than 10,000 renal transplants performed annually for patients with end-stage renal disease. PTLD occurs in 1 to 2 percent of kidney transplants, with mortality ranging from 50 to 70 percent. PTLD may develop following kidney or other organ transplants when EBV-infected B lymphocytes proliferate uncontrollably in the absence of the infection-fighting immune cells that normally keep them in check.

Its a tricky complication to treat successfully.

A multidisciplinary team of physicians and scientists at the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Ohio State University Comprehensive Cancer Center, however, says it has had significant success treating PTLD using a two-part therapy that includes the use of the antiviral drug acyclovir along with gradual reductions in patients immunosuppressive drugs. By reducing the doses of the drugs that suppress the rejection of the transplanted organ and the function of the normal immune system, the immune mediators that recognize and kill EBV-infected cancer cells are allowed to do their job.

Drs. Pierluigi Porcu and Charles Eisenbeis, oncologists at The James, used the approach with 11 consecutive kidney transp

Contact: Michelle Gailiun
Ohio State University Medical Center

Page: 1 2 3

Related medicine news :

1. OHSU scientists develop MRI approach to improve breast cancer detection
2. Trial reveals safer and simpler approach to treating children with cystic fibrosis
3. Services for children: Training needed to tackle complexity of new labours joined-up approach
4. Government approach to cutting hospital stays may be misleading
5. Is the 3 by 5 initiative the best approach to tackling the HIV pandemic?
6. Animal study suggests safer immunization approach to Alzheimers
7. Worldwide approach tackles kidney disease
8. Texas Childrens Hospital specialists say proactive approach best defense against flu season
9. Endoscopic approach best for repairing bone defect between brain, nasal cavity
10. University of Pittsburgh approach has lung recipients taking far fewer drugs
11. Tissue involved in brain development may offer new approach to stroke treatment

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: