New approach to post-transplant lymphoma shows promise

COLUMBUS, Ohio - Scientists may be making significant headway in treating one of the most difficult and often fatal complications of organ transplant, PTLD, or post-transplant lymphoproliferative disorder.

PTLD is a form of lymphoma, or cancer of the glands of the lymph system, associated with the presence of the Epstein-Barr virus (EBV). Normally, EBV itself is not threatening - scientists say 90-95 percent of us carry it in our systems all the time. But it poses special problems for transplant patients because the drugs they have to take to keep their body from rejecting new organs weaken the immune system and create the perfect environment for the virus to spring into action.

Kidney transplants are among the most common transplants in the United States, with more than 10,000 renal transplants performed annually for patients with end-stage renal disease. PTLD occurs in 1 to 2 percent of kidney transplants, with mortality ranging from 50 to 70 percent. PTLD may develop following kidney or other organ transplants when EBV-infected B lymphocytes proliferate uncontrollably in the absence of the infection-fighting immune cells that normally keep them in check.

Its a tricky complication to treat successfully.

A multidisciplinary team of physicians and scientists at the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Ohio State University Comprehensive Cancer Center, however, says it has had significant success treating PTLD using a two-part therapy that includes the use of the antiviral drug acyclovir along with gradual reductions in patients immunosuppressive drugs. By reducing the doses of the drugs that suppress the rejection of the transplanted organ and the function of the normal immune system, the immune mediators that recognize and kill EBV-infected cancer cells are allowed to do their job.

Drs. Pierluigi Porcu and Charles Eisenbeis, oncologists at The James, used the approach with 11 consecutive kidney transp

Contact: Michelle Gailiun
Ohio State University Medical Center

Page: 1 2 3

Related medicine news :

1. OHSU scientists develop MRI approach to improve breast cancer detection
2. Trial reveals safer and simpler approach to treating children with cystic fibrosis
3. Services for children: Training needed to tackle complexity of new labours joined-up approach
4. Government approach to cutting hospital stays may be misleading
5. Is the 3 by 5 initiative the best approach to tackling the HIV pandemic?
6. Animal study suggests safer immunization approach to Alzheimers
7. Worldwide approach tackles kidney disease
8. Texas Childrens Hospital specialists say proactive approach best defense against flu season
9. Endoscopic approach best for repairing bone defect between brain, nasal cavity
10. University of Pittsburgh approach has lung recipients taking far fewer drugs
11. Tissue involved in brain development may offer new approach to stroke treatment

Post Your Comments:

(Date:8/28/2020)... ... August 28, 2020 , ... ... designed to help treat patients with respiratory conditions, including COVID-19, while reducing the ... and oxygen, but it captures exhaled gas and scrubs it free of carbon ...
(Date:8/28/2020)... ... 28, 2020 , ... With in-person gluten-free events being canceled ... the specialty-diet community connect with great, gluten-free brands. At the Online Nourished ... with brands & watch over 50 educational classes... all online from the comfort ...
(Date:8/28/2020)... CHICAGO (PRWEB) , ... August 28, 2020 , ... ... its role in advising Adventist Health on its investment in Synchronous Health, a ... health company that combines the strength of human empathy with artificial intelligence (AI) ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... ... has joined the Walk-in Dermatology team in its Greenvale, New York location. ... Nail and Skin Care Institute. She is certified in chemical peels, microdermabrasion, Hydrafacial ...
(Date:8/27/2020)... ... August 27, 2020 , ... Evolution Labs announced today that ... students with Suite360:Mental Health and Prevention, a program developed to help students navigate ... Prevention. , Florida schools and districts must provide their students with preventative lessons ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... 2020 , ... Mara C. Weinstein Velez, M.D., FAAD is ... of Rochester Medical Center, in Upstate New York. She completed a prestigious Laser, ... from the Harvard and Yale Departments of Dermatology and is one of the ...
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase ... schools and community organizations remain closed. Because about 80% of blood donations are made ... both blood donors and blood drive hosts to ensure blood products are readily available ...
(Date:9/1/2020)... ... ... September is National Ovarian Cancer Awareness Month. Ovarian cancer is the 5th deadliest ... reproductive system. The American Cancer Society estimates that in 2020, about 22,000 women ... disease. Throughout the month of September, Women’s Excellence aims to increase understanding of ...
Breaking Medicine Technology:
Cached News: