New awards, expanded focus for Pediatric AIDS Clinical Trials Group

Group has been instrumental in forging new prevention and treatment strategies for HIV-infected mothers and their children, and in working to extend and improve the quality of their lives," says Anthony S. Fauci, M.D., director of NIAID. "As the global scope of the epidemic evolves, the PACTG will continue to tackle the most critical needs in pediatric and adolescent HIV/AIDS research both in the United States and the developing world."

The new research agenda of the PACTG emphasizes five key areas:

  • Perinatal Transmission: continue studying the safety of antiretroviral drugs in HIV-infected pregnant women; continue translational research for resource-poor international partners; and examine why current interventions are not fully successful.
  • Pediatric Treatment: study the safety of new drugs, the best use of available drugs and treatment management; and evaluate the effect of interventions on the course of the disease.
  • Adolescent Treatment: expand adolescent research to every PACTG site; study the effects of treatment on acute and early infection and on restoration of immune function; and promote collaborations to assist in prevention research, including behavioral research.
  • Long-Term Evaluation of Antiretroviral Therapies: increase commitment to long-term pediatric studies; study drug safety in infants who escape infection and in children who become infected; and link durability of treatment responses to clinical outcomes.
  • Domestic and International Collaborations: collaborate with other NIH-sponsored domestic and international HIV/AIDS therapeutic and prevention trials networks; encourage scientific exchange and resource-sharing with international partners; and conduct international studies of interventions that can be readily transferred to developing countries.


Before the PACTG was established, clinical studies of HIV-positive mothers, children a

Contact: Diana K. Carroll
NIH/National Institute of Allergy and Infectious Diseases

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