New awards, expanded focus for Pediatric AIDS Clinical Trials Group

nd adolescents were carried out and funded through NIAID's AIDS Clinical Trials Group (ACTG). In 1995, an independent review panel recommended the PACTG become a separate entity from the ACTG. The PACTG was established as an independent network in 1997 and now comprises 18 Pediatric AIDS Clinical Trials Units funded by NIAID, and 35 domestic and international sites funded by the National Institute of Child Health and Human Development. To date, the PACTG has initiated 113 clinical trials and, as of December 2001, has enrolled approximately 27,432 women and children. Some noteworthy studies and findings include:

  • The landmark study showing that AZT given to HIV-positive pregnant women and their newborns shortly after birth can greatly reduce the rate of HIV transmission (ACTG 076).
  • Long-term follow-up studies of infected and uninfected but antiretroviral-exposed infants.
  • Studies demonstrating that multi-agent combination treatment of HIV-infected pregnant women can lead to very low rates of HIV transmission to their infants.
  • Numerous studies in HIV-infected women and children to determine appropriate doses of antiretrovirals and other drugs in these populations.
  • Studies evaluating the use of highly active antiretroviral combinations in children, which contributed to establishing the standard of care for antiretroviral therapy in children.
  • Research evaluating the restoration of immune responses after initiation of potent combination therapies.
  • Studies elucidating the differences in the pathogenesis of acute HIV infection in infants compared with infection acquired by adolescents or adults.

For more information on pediatric or adult clinical trials, contact the AIDS Clinical Trials Information Service at 1-800-TRIALS-A (1-800-874-2572), 12 p.m. to 5 p.m. Eastern Time, Monday through Friday. Bilingual health specialists are available. You can also visit their Web site at

Contact: Diana K. Carroll
NIH/National Institute of Allergy and Infectious Diseases

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