HOME >> MEDICINE >> NEWS
New clue to nerve growth may help regeneration efforts

Johns Hopkins scientists have discovered how one family of proteins repels growing nerves and keeps them properly on track during development. The finding, described in the Dec. 16 issue of Neuron, might provide a chance to overcome the proteins' later role in preventing regrowth of injured nerves, the researchers say.

The proteins, known as chondroitin sulfate proteoglycans (CSPGs), have long been known to prevent nerve regeneration after injury by recruiting a stew of other proteins and agents, but exactly what part of the mix keeps nerves from regrowing is unknown.

In studies of nerve growth in developing rats, the Hopkins scientists have linked CSPGs' no-growth effects to a protein called semaphorin 5A. The scientists, including David Kantor, an M.D./Ph.D. candidate, found that when CSPGs bind to semaphorin 5A, growing nerves are stopped in their tracks. Blocking this particular interaction freed the nerves to continue growing.

"CSPGs are a critical obstacle to nerve regeneration after injury, and without details about what's really happening, it's impossible to rationally intervene," says study leader Alex Kolodkin, Ph.D., professor of neuroscience in Johns Hopkins' Institute for Basic Biomedical Sciences. "We studied nerve growth, rather than re-growth, but our work provides a starting point for identifying more partners of CSPGs and for finding targets to try to counter these proteins' effects in nerve regeneration."

Semaphorins, including 5A, are a family of proteins that help direct growing nerves as they extend toward their eventual targets, largely by keeping nerves out of places they shouldn't be.

"These proteins are classic 'guidance cues' for nerves. There's nothing particularly fancy about what they do -- they bind to spots on the tip of the growing nerve, and the nerve doesn't continue going in that direction," says Kolodkin, whose lab studies semaphorins. "Scientists studying CSPGs' effects haven't rea
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
15-Dec-2004


Page: 1 2 3

Related medicine news :

1. Schepens scientists regenerate optic nerve for the first time
2. An implanted nerve stimulator helps drop foot sufferers walk faster and better
3. Engineers develop biowarfare sensing elements for future highly sensitive nerve-gas detectors
4. Drug treatment promising for halting Huntingtons-related nerve death
5. Wisconsin scientists grow critical nerve cells
6. Antibody treatment partially reverses nerve damage in Alzheimer disease
7. Antibiotics protect nerves in mice by turning on genes
8. Replicating an eels nerve circuitry may aid paralyzed people
9. Skeletal muscle cells could be source of stem cells for regenerating nerve tissue
10. Protein not only aids nerve development, but promotes blood vessel growth, too
11. Research on nerve cell circuitry reveals clue about schizophrenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... ... joining the clinically integrated network (CIN) and the group purchasing organization run by ... Institute to establish a heart failure program at Mon Health Medical Center. ...
(Date:5/28/2020)... ... May 28, 2020 , ... ... re-open in the fall, operators of student housing are scrambling to implement practices ... which manages over 37,000 student housing beds on 38 campuses across the country, ...
(Date:5/27/2020)... ... , ... The podiatrists and foot doctors of Advanced Foot & Ankle Specialists ... Ann Arbor Michigan. Dr. Tomasz Biernacki states that “Podiatrists can help support ... hospital. We have been seeing patients in the hospital for the past 3 months, ...
(Date:5/27/2020)... ... May 27, 2020 , ... ... Washington Professor of Bioengineering, Founder & Editor of scientific journal WATER, author ... https://www.amazon.com/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2 ) , https://www.voiceamerica.com/episode/123059/the-fourth-phase-of-water , * , During the ...
(Date:5/26/2020)... Mich. (PRWEB) , ... May ... ... RevSpring today announced the availability of two leading RevSpring solutions—Talksoft® patient messaging ... Patient Payment platform by engaging patients through automated and precise texts, IVR ...
Breaking Medicine News(10 mins):
(Date:6/2/2020)... , ... June 02, 2020 , ... ... well as screening tools, has strengthened its commitment to meeting today’s highest standards ... for use in molecular pharmacology, early stages of drug discovery, screening of chemical, ...
(Date:5/30/2020)... ... 2020 , ... United Nations Foundation President and CEO Elizabeth ... will terminate its relationship with the World Health Organization (WHO): , “We are ... with the World Health Organization. Any move of this kind will severely impede ...
(Date:5/30/2020)... (PRWEB) , ... May 30, 2020 , ... ... are dealing with a host of new issues related to COVID-19. Recently, Wellness ... tips to help expectant moms support their pregnancy and postpartum. , A ...
Breaking Medicine Technology:
Cached News: