New data on the effect of Atacand(R) on NYHA class in a broad spectrum of heart failure patients

Mlndal, Sweden, 9 March 2004 Data presented today at the American College of Cardiology (ACC) annual meeting add weight to the evidence shown in the original publications from the CHARM* Programme of the effects of Atacand (candesartan cilexetil) in chronic heart failure (CHF) patients. The results from further analysis of the data add further support for the CHARM study as a landmark clinical research programme.

Importantly, one analysis1 found that New York Heart Association (NYHA) functional class improved in a broad spectrum of CHF patients treated with Atacand. Of all CHARM patients, 35.4% taking Atacand improved in NYHA functional class, 55.6% remained unchanged and 9% worsened. This compared with 32.5%, 57.5% and 10.3% respectively in the placebo group (p=0.004). These findings were supported by a favourable change in the Overall Treatment Evaluation in the Atacand group compared to the placebo group (p=0.01).

Commenting on this additional analysis, Professor John McMurray, principal investigator in the CHARM-Added study, Glasgow University and Western Infirmary, Glasgow, Scotland, said "Improving symptomatic well-being is a key objective of heart failure treatment. NYHA functional classification is the most widely used and validated measure of symptomatic limitation in CHF. That candesartan has been shown to improve NYHA functional class across the broad spectrum of CHF investigated in the CHARM Programme will have significant implications for clinical practice. These findings are consistent with a reduction in CHF hospitalisations".

A further analysis suggests that the development of atrial fibrillation (AF) in some patients with symptomatic chronic heart failure may also be reduced. Of the 7,601 heart failure patients in CHARM, 72.6% did not have atrial fibrillation (AF) at baseline. This new analysis found that, in the patients randomised to Atacand, new incidence of AF during the trial was 6.5%, compared to 7.9% in the place

Contact: Mark Chamberlain

Page: 1 2

Related medicine news :

1. Strategy effective against drug resistant tuberculosis
2. Study shows patch therapy may be as effective as oral medications
3. Chronic pain treatments more effective when taken together, new study shows
4. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints
5. Brain activity prior to treatment flags vulnerability to antidepressant side effects
6. Improving access to healthy food has little effect on diet
7. Storage time and temperature effects nutrients in spinach
8. Costs of antidepressants could have funded effective alternatives
9. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS
10. Government wasting your taxpayer money on ineffective drug cure
11. Neurobehavioral function during coma, stroke rehabilitation effective for elderly

Post Your Comments:

(Date:11/30/2015)... ... November 30, 2015 , ... According to Los Angeles bariatric surgeon ... are not necessarily caused by real hunger, but instead by a hormone called ... notes that, while many patients are aware that weight loss surgery can help patients ...
(Date:11/30/2015)... ... November 30, 2015 , ... RoamRight, a leading provider of ... Public Television’s Travel With Kids to promote family vacations around the world. ... they explore international destinations and educate families about the people and places of the ...
(Date:11/30/2015)... ... , ... At Grand Dental PC, their priority is to deliver quality care ... problems, you need to turn to a dentist who listens and responds; an experienced ... friendly dentist who counsels you on the best ways to maintain and improve your ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... specializes in general dentistry out of Glen Ridge, NJ. He has both ... to achieve optimal mastication. He is also an expert in cosmetic dentistry. ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting of ... December 1, 2015, to coincide with World AIDS Day. The multi-media project will be ... the AIDS epidemic as he was dying of the disease. , A collaborative effort ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... PUNE, India , December 1, 2015 ... --> ReportsnReports.com adds "Endometriosis - ... that provides an overview on therapeutic pipeline ... capabilities to create effective counter strategies to ... by identifying new targets and MOAs to ...
(Date:11/30/2015)... DUBLIN , Nov. 30, 2015 ... addition of the "Orphan Drugs Market 2015-2019" ... http://www.researchandmarkets.com/research/pj37pz/orphan_drugs ) has announced the addition of the ... their offering. --> Research and Markets ... the "Orphan Drugs Market 2015-2019" report ...
(Date:11/30/2015)... 30, 2015   Royal Philips (NYSE: ... industry,s first MRI guided user interface and automatic scan ... with MR Conditional implants, such as knee and hip ... Radiological Society of North America Annual Meeting (RSNA) . ... diagnostic confidence of this growing patient population. ScanWise Implant ...
Breaking Medicine Technology:
Cached News: