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New data show SPIRIVA significantly reduces COPD exacerbations and related health resource burden

GLASGOW, UNITED KINGDOM, Tuesday 7 September SPIRIVA (tiotropium) significantly reduced exacerbations and health resource utilization compared with placebo in patients with Chronic Obstructive Pulmonary Disease (COPD), according to data presented today at the annual European Respiratory Society meeting in Glasgow, Scotland.1,2 SPIRIVA is a novel, inhaled, anticholinergic medication with 24-hour efficacy3 recommended for maintenance treatment of COPD. SPIRIVA provides superior symptom relief and sustained improvement in lung function vs placebo so that patients with COPD can regain a better quality of life.3-5

COPD is a progressive respiratory disease that causes significant deterioration of lung function and chronic breathlessness, which can lead to severe disability.6 Chronic airflow limitation associated with COPD leads to excess air being trapped in the lungs after a person has fully exhaled. This condition, known as "air trapping", is a primary cause of breathlessness, which often restricts a patient's ability to perform daily activities such as walking up stairs or taking a shower.3,7 Currently, COPD is the fourth leading cause of death worldwide, claiming 2.75 million lives annually.8

"Current guidelines state that exacerbations, or acute worsening of disease symptoms, are a key target for COPD therapy because they severely impact quality of life, and are responsible for the majority of healthcare costs associated with treating COPD," said Professor Daniel Dusser, Head of Pneumology, Hpital Cochin, Paris and principal study investigator.

In this one-year, placebo-controlled study involving 1,010 patients with COPD in 177 centres in France, SPIRIVA was shown to significantly reduce the frequency of exacerbations compared to placebo (1.57 vs 2.41 per patient per year, -35%, p<0.01).1 The average number of exacerbation days was significantly lower with SPIRIVA c
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Contact: Patrick Ward
patrick.ward@shirehealthinternational.com
44-207-471-1523
Shire Health International
7-Sep-2004


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