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New data show SPIRIVA significantly reduces COPD exacerbations and related health resource burden

ompared to placebo (21.1 vs 33.3 per patient per year, -37%, p<0.01), and the time to first exacerbation was also significantly prolonged (p<0.001).1

The reduction in exacerbations with SPIRIVA was also associated with significantly lower health resource utilization.2 The following was observed compared to placebo:

  • Significantly fewer unscheduled physician visits and phone calls to physicians per patient per year (-41%, p=0.0106 and -53%, p=0.0122 respectively)
  • Hospitalizations were reduced per patient per year (-27%, p>0.05)
  • Significantly fewer patients required additional respiratory medications for their exacerbations (30.5% vs 42.5%, p<0.0001)
  • Significantly fewer courses of antibiotics (-34%, p=0.0005) and oral steroids (-24%, p=0.0083) were required per patient per year
  • Significantly fewer patients required oxygen (2.6% vs 5.3%, p=0.027).

"The results of this study reinforce the effectiveness of SPIRIVA as a maintenance therapy that significantly reduces COPD exacerbations, improving patient quality of life and reducing the related burden on health resources," Professor Daniel Dusser said.

In this study, exacerbations were defined as the onset of 1 clinical symptom in the past 24 hours (worsening of dyspnoea, cough or sputum production; appearance of purulent sputum; fever [>38C] or appearance of new chest X-ray abnormality) requiring a new prescription, or an increase in the dose, of b2-agonists, antibiotics, corticosteroids or bronchodilators.

About SPIRIVA (tiotropium)
SPIRIVA, an inhaled anticholinergic medication, is the first inhaled treatment to provide significant and sustained improvements in lung function, with once-daily dosing. SPIRIVA works through targeting of a dominant reversible mechanism of COPD cholinergic bronchoconstriction. SPIRIVA helps COPD patients breathe more easily by opening narrowed air
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Contact: Patrick Ward
patrick.ward@shirehealthinternational.com
44-207-471-1523
Shire Health International
7-Sep-2004


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