in children with a kidney transplant
Jungraithmayr TC, Tnshoff B, Zimmerhackl LB, et al. Mathematical modelling to predict renal function and graft survival based on 5 year data of paediatric renal transplant patients with mycophenolate mofetil (MMF) versus azathioprin (AZA) based immunosuppression. Abstract 1355, ATC 2004.
CellCept-based immunosuppressant regimens lead to longer-term healthy graft function and survival in children (89.9%), when compared to AZA-based therapies (73.1%). This is according to data revealed through a novel mathematical model, which outlined future graft survival and functioning rates based on existing five-year data. In addition, CellCept maintained normal creatinine levels an indicator of healthy kidney function for twice as long as the AZA group (14.5 years versus 6 years).
in allograft dysfunction in adult patients
Two further studies reinforced CellCept's position as central to a safe, effective and tolerable immunosuppressant regimen.
Fonseca CC, Felipe CR, Motegi SA, et al. Conversion from cyclosporine/sirolimus (CsA/SRL) to mycophenolate mofetil/sirolimus (MMF/SRL) in patients with chronic allograft dysfunction. Abstract 226, ATC 2004.
In a study of 182 transplant patients where 81 patients presented with allograft dysfunction, conversion from CNI/sirolimus to CellCept/sirolimus in patients with chronic allograft dysfunction is a potential effective and safe strategy to preserve graft function.