04.
Further data shows CellCept's CNI-sparing benefit in patients with impaired graft kidney function given a 50% reduced dose of CNI, within a CellCept-based immunosuppressant regimen. Results indicate that over two years, kidney function within the CellCept group improved, whereas the CNI/azathioprine (AZA) group saw no improvements in graft function.

in children with a kidney transplant
Jungraithmayr TC, Tnshoff B, Zimmerhackl LB, et al. Mathematical modelling to predict renal function and graft survival based on 5 year data of paediatric renal transplant patients with mycophenolate mofetil (MMF) versus azathioprin (AZA) based immunosuppression. Abstract 1355, ATC 2004.
CellCept-based immunosuppressant regimens lead to longer-term healthy graft function and survival in children (89.9%), when compared to AZA-based therapies (73.1%). This is according to data revealed through a novel mathematical model, which outlined future graft survival and functioning rates based on existing five-year data. In addition, CellCept maintained normal creatinine levels an indicator of healthy kidney function for twice as long as the AZA group (14.5 years versus 6 years).

in allograft dysfunction in adult patients
Two further studies reinforced CellCept's position as central to a safe, effective and tolerable immunosuppressant regimen.

Fonseca CC, Felipe CR, Motegi SA, et al. Conversion from cyclosporine/sirolimus (CsA/SRL) to mycophenolate mofetil/sirolimus (MMF/SRL) in patients with chronic allograft dysfunction. Abstract 226, ATC 2004.
In a study of 182 transplant patients where 81 patients presented with allograft dysfunction, conversion from CNI/sirolimus to CellCept/sirolimus in patients with chronic allograft dysfunction is a potential effective and safe strategy to preserve graft function.

Alves EC, Felipe CR, Park SI, et al. Long-term effects of the conversion from azath
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Contact: Cendrine Banerjee-Quetel
cendrine.banerjee-quetel@ketchum.com
44-207-611-3656
Ketchum
19-May-2004

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