New drug may reverse bone loss without estrogens side effects, Science study says

This news release is also available in French.

A synthetic compound called "estren" helped build bone, without affecting the reproductive organs of both female and male mice, a new study reports. If the same holds true for humans, these findings may suggest an alternative to standard hormone replacement therapy for treating osteoporosis, the authors say. The study appears in the journal Science, published by the American Association for the Advancement of Science.

Osteoporosis affects millions of people worldwide, many of them post-menopausal women.

"For a long time we have been giving hormone replacement to women, based on the evidence that estrogens are effective in preventing osteoporosis. The big assumption was that estrogen worked the same way in all the tissues," said study author Stavros Manolagas of the University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System

Along with their bone-related benefits, however, estrogen supplements can also have unwanted effects in the body's reproductive tissues, according to Manolagas. For example, they can modestly increase the risk of breast and uterine cancer. Several months ago, a major clinical study on the long-term use of estrogen plus progesterone found that these risks, as well as others, outweighed the therapy's benefits. The news left many women in a quandary about whether to continue their therapy.

"Our study shows you can have the benefits [of estrogen] on non-reproductive tissues, without having the side effects," Manolagas said. "This is a brand new page of pharmacology."

Estren may be useful for preventing osteoporosis in men as well as women. Because androgen stimulates prostate cancer, men with the disease typically have their prostate removed or take androgen-inhibiting drugs, leaving them vulnerable to osteoporosis.

"It's very exciting that t

Contact: Lisa Onaga
American Association for the Advancement of Science

Page: 1 2 3

Related medicine news :

1. Antibody treatment partially reverses nerve damage in Alzheimer disease
2. Nerve damage from alcoholism reversed after liver transplantation
3. Pioglitazone shown to reverse thickening of carotid artery wall
4. Obesity reversed in mice by destroying blood vessels that service fat cells
5. Testing drugs ability to reverse stroke after standard three-hour window has closed
6. Corkscrew device retrieves clots, quickly reverses stroke damage
7. Stanford research shows targeted DNA vaccine may reverse autoimmune disease
8. Strong statin therapy reverses plaque build-up in arteries
9. Chiropractic correction of upper neck injury may help reverse multiple sclerosis
10. Experimental drug reverses effects of Fabry disease in mice
11. New treatment might reverse memory loss in those with schizophrenia, Parkinsons, and other disorders

Post Your Comments:

(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: