HOME >> MEDICINE >> NEWS
New drug protects against the hardening of arteries

Atherosclerosis, a leading cause of morbidity and mortality in Western nations, is caused by the accumulation of cholesterol-rich lipoproteins that adhere to vessel walls and develop into macrophages. These macrophages, laden with lipid, cause inflammation in the vessel and, over time, formation of a lesion. A family of proteins known as PPARs (PPARalpha, PPARbeta, and PPARgamma) are expressed by cells of the artery wall and drugs that activate PPARalpha and PPARgamma (known as PPAR agonists) are used to treat high lipid levels (such as cholesterol and triglycerides), and type 2 diabetes, respectively. The presence of PPARs in the vessel wall has prompted researchers to investigate the effects of PPAR agonists on atherosclerosis in mice. While studies have shown that PPARgamma agonists are beneficial in the treatment of atherosclerosis in mice, the role of other members of this protein family have remained unclear.

In the December 1 issue of the Journal of Clinical Investigation, Andrew Li and colleagues from the University of California, San Diego compare the effects of PPARalpha, PPARbeta, and PPARgamma agonists on the development of atherosclerosis in a mouse model of this disease. They observed profound protective effects of the PPARalpha agonist GW7647, comparable to the PPARgamma agonist rosiglitazone that is currently used to treat type 2 diabetes. GW7647 also reduced weight gain, and insulin and lipoprotein levels. In contrast, lesion development was not inhibited by a PPARbeta agonist.

In an accompanying commentary, Peter Tontonoz and Antonio Castrillo from the University of California, Los Angeles discuss the mechanism described by Li and colleagues by which lipid accumulation is reduced by these agonists, thereby giving us a greater understanding of the roles of PPAR family members in atherosclerosis. Most importantly, the study highlights that the use of a drug (or drugs) that target multiple PPARs, particularly PPARalpha and PPARgamma,
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-0497
Journal of Clinical Investigation
1-Dec-2004


Page: 1 2

Related medicine news :

1. Red wine protects the heart
2. Component of green tea protects injured livers in mice
3. Substance protects resilient staph bacteria
4. Gene vaccine protects mice against development of Her2/neu breast cancer
5. Blocking molecules protects health of implants
6. Good parenting protects against chronic illness says professor of public health
7. Exercising limbs protects brain cells affected by Parkinsons, study in rodents shows
8. Mechanism found that protects aggressive melanoma from angiogenesis inhibitors
9. Chicken pox vaccine saves $$, protects whole population
10. Diet of worms protects against bowel cancer
11. NIAID vaccine protects against SARS virus infection in mice

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New drug protects against the hardening arteries

(Date:5/23/2015)... Dr. David Benvenuti, an experienced plastic surgeon ... new article to his website that takes an ... explained in the fascinating blog, he has recently had ... , Known as “gauging,” the technique involves placing larger and ... said will eventually stretch the holes out to incredible sizes. ...
(Date:5/23/2015)... 2015 On Wednesday, May 20, 2015, ... has been the target of a sophisticated cyberattack,” and ... company’s ongoing Information Technology (IT) security efforts in the ... The most notable attack on health insurers was reported ... nation’s second largest health insurer, revealed that they had ...
(Date:5/23/2015)... 2015 Manufacturers are now required to produce ... of 8.2. Experts in the field agree that the regulation ... The HSPF score is what miles per gallon is to ... unit. Although the minimum HSPF score has been raised to ... HSPF score north of 12. Indeed, the regulation was welcomed ...
(Date:5/23/2015)... Janesville, WI (PRWEB) May 23, 2015 ... Mercy Acceleration at the Sports Medicine and Rehabilitation Center, ... running clinic program, Mondays, June 1-July 20, 5:30-6:30 pm. ... MS, USAT coach, and Laurie Finke, RN, BSN, who ... flexibility exercises, education on nutrition, running mechanics and show ...
(Date:5/23/2015)... MD (PRWEB) May 23, 2015 Injury lawyer ... that has been passed by the Maryland legislature but which ... “The Maryland General Assembly passed HB 449 with ... Governor has not signed it into law. This bill ensures ... Evidence is growing that demonstrates the danger of fracking to ...
Breaking Medicine News(10 mins):Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3
(Date:5/22/2015)... HILL, N.C. , May 22, 2015 /PRNewswire/ ... critical to pharmaceutical brand recognition and success. ... LLC conducted a study to provide pharmaceutical and ... of investment (FTEs and budget) that are being ... Pharmaceutical and biotech marketing managers can utilize this ...
(Date:5/22/2015)... 22, 2015 The North American dental ... is estimated to reach $90.7 million by 2019, at a ... through the TOC of North America Dental Lasers Market for ... of various tables and figures. http://www.micromarketmonitor.com/market/north-america-dental-lasers-1771208223.html ... this report.   Dental lasers are specifically ...
(Date:5/22/2015)... , May 22, 2015  The Mesothelioma ... diagnosed victims of mesothelioma get the best possible ... certain individuals with this rare cancer caused by ... most up-to-date information related to treatment options such ... please call the Mesothelioma Victims Center anytime at ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5
Cached News: