HOME >> MEDICINE >> NEWS
New evidence eases some concerns about bone fracture risk with breast cancer drug

Copenhagen, Denmark: New evidence about the breast cancer drug anastrozole (Arimidex) shows that the incidence of a major side-effect bone fractures appears to stabilise after reaching a peak at two years of treatment, easing some of the concerns about the drug.

This finding is the latest to come from evidence provided by the world's largest international study of breast cancer treatment, the ATAC[1] trial, which compared the aromatase inhibitor anastrozole with breast cancer's current gold standard hormone treatment tamoxifen, and with both treatments combined.

The trial, involving more than 9,000 post menopausal women in 21 countries, last year revealed that over a median follow-up of patients of 33 months, anastrozole enhanced disease-free survival by 19% and cut the incidence of new tumours in the opposite breast by 58% compared to tamoxifen. This represented an absolute difference of 1.8% in favour of anastrozole. An update at 47 months median follow up showed that the gap had widened to an absolute difference of 2.6% in favour of the newer drug. Overall survival comparisons from the trial should be available next year.

Professor Anthony Howell, chairman of the ATAC steering committee, told a news briefing at ECCO 12 the European Cancer Conference, that while it was clear that further results were adding to the evidence that anastrozole may in the future supplant tamoxifen doctors needed to be cautious. "We should still wait for that overall survival data next year," he said.

A concern about anastrozole has been the risk of bone fractures. Depriving the body of oestrogen reduces the risk of breast cancer recurring because many breast cancers 'feed' off this hormone. But, one consequence of oestrogen deprivation is that bones become vulnerable. Aromatase inhibitors such as anastrozole produce profound oestrogen deprivation so it would not be unexpected that women on anastrozole might be more at risk of fractures than those on
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
45-3252-4163
Federation of European Cancer Societies
24-Sep-2003


Page: 1 2 3

Related medicine news :

1. More evidence of cannabis-induced psychosis
2. Not enough evidence that multivitamins prevent infections in the elderly
3. Emotional memory study reveals evidence for a self-reinforcing loop
4. Influenza vaccination programmes for children in USA and Canada based on little evidence
5. Scientific evidence for diets: dont believe everything you read
6. New evidence of retroviral involvement in amyotrophic lateral sclerosis
7. Two studies find evidence that sunlight may have beneficial influence on cancer
8. Study finds no evidence of a cancer personality
9. Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
10. USC researchers find evidence that progesterone signaling influences ovarian cancer risk
11. Chamomile tea: New evidence supports health benefits

Post Your Comments:
(Date:11/21/2014)... City, Mo (PRWEB) November 21, 2014 ... received the Get With The Guidelines®–Heart Failure Gold-Plus ... measures outlined by the American Heart Association/American College ... for heart failure patients. , Get With The ... helps hospital teams provide the most up-to-date, research-based ...
(Date:11/21/2014)... Big Bud Farms announced today that they ... with Ed Begley Jr., airing via Discovery Channel 2nd ... Bud Farms, growers of legal medical marijuana, provide the ... medical marijuana. , This segment of Innovations takes a ... products for medicating. Viewers will learn about the resources ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 Recently, ... and launched a wedding dress promotion for the coming ... enjoy a special offer when checking out. , The ... in 2014. The customers like the designs for the ... VogueQueen.com would not only be good for the environment, ...
(Date:11/21/2014)... Washington, DC (PRWEB) November 21, 2014 ... of Atlantic Information Services, Inc.’s (AIS) annual Directory of ... health plan market. AIS’s Directory of Health Plans is ... for health plans operating in the U.S. The ... So far, researchers in AIS’s Directory and Databases Division, ...
(Date:11/21/2014)... Ft. Lauderdale, Florida (PRWEB) November 21, 2014 ... system for chronic headaches and other jaw-related ... of patients seeking relief from chronic head pain, neck ... vertigo. , “This year we have seen a ... have treated. Our network of over 300 doctors and ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 2Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 3Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 4Health News:Big Bud Farms to be Featured in Upcoming Episode of Innovations with Ed Begley Jr. 2Health News:Beach Wedding Dresses on Sale for the Coming Holiday Season at VogueQueen.com 2Health News:Data from Atlantic Information Services’s Forthcoming Directory Shows Volatility in U.S. Health Care Market 2Health News:National Rise In Patients Seeking Headache Relief 2
(Date:11/21/2014)... Nov. 20, 2014  RedRick Technologies, a provider ... reading room environment guidance, has helped the new ... reading room, which may also serve as a ... Medicine. "In line with the ... of Radiology,s Imaging 3.0 ™ initiative, the ...
(Date:11/21/2014)... 21. November 2014 Michael DeMarco ... Morgen des 14. Februar 2014 zugetragen hat. Seine Tochter ... vergessen. Video - http://youtu.be/5cVoMCe0uiE ... war, mein morgendliches Training zu machen", erzählt Michael ... der Zeit begeisterte Anhänger der CrossFit-Trainingsmethode. Ich war ...
(Date:11/21/2014)... Nov. 20, 2014 Oxis International, Inc. (OXIS) (OXI.PA) ... election of Anthony J. Cataldo as Chief Executive ... Effective November 19, 2014, Ken Eaton resigned his ... of Directors of Oxis International, Inc. to pursue new opportunities. ... named Chief Executive Officer of Oxis International, Inc. Mr. Cataldo ...
Breaking Medicine Technology:RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 3OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3
Cached News: