New finding could make addiction treatment more effective

a truly normal state. In the meantime, sleep problems can get worse. Insomnia has been shown to occur in 36 percent to 72 percent of alcoholic patients during both active drinking and withdrawal.

"There is a significant relationship between alcoholics returning to consumption because of this sleep issue," said Godwin, an associate professor of neurobiology and anatomy. "One reason they may go back to drinking may be an attempt to make their sleep feel more normal or satisfying."

Previous research has shown that alcohol affects spindle waves, which are brain rhythms associated with normal sleep. The primary generators of spindle waves are proteins called calcium channels that are involved with cell communication. These channels may also help to set the phase of sleep.

Chronic alcohol consumption has been shown to disturb the function of calcium channels in the thalamus, a brain region involved in sleep. In the current study, Godwin and colleagues found that animals that self-administered alcohol had a fourfold increase in one of the genes that express the calcium channels, compared to animals that didn't consume alcohol.

"The alcohol suppresses the calcium channels, so the cells in the thalamus may compensate by making more copies of the gene," said Godwin. "However, this overproduction of the gene did not lead to an increase in functional calcium channels and the cells still had disturbances in the channels, so the animals as a group tended to have disrupted sleep."

Godwin and colleagues plan to continue the work to learn how alcohol disrupts the protein. Does it reduce the number of calcium channels? Or does it cause the channels to malfunction? Knowing more about how the channels respond to alcohol could lead to drugs that could target the calcium channels and address sleep problems associated with alcohol.


Contact: Karen Richardson
Wake Forest University Baptist Medical Center

Page: 1 2

Related medicine news :

1. Statement on the findings of the Womens Health Study
2. Latest findings on genetic blood disorder Cooleys Anemia
3. Hard choices: Pitt researcher presents findings on when to accept organ transplants
4. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
5. Medical meeting to feature research findings and disease prevention and health promotion sessions
6. New findings on patient safety at childrens hospitals
7. Nerve navigation findings prompt new direction for spinal cord research
8. Center refutes finding that added sugars displace vitamins and minerals
9. Testosterone may help in recovery from strokes, suggests preliminary findings in study
10. Study findings question claims of significant savings from pharmacy dose consolidation programs
11. Some positive findings in new study on cocaine exposed children

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... ... be the focus of Fall 2020 Virtual Conference, a two-day virtual event for ... Enterprise Imaging & Beyond" is the follow-up to AuntMinnie.com's successful virtual event in ...
(Date:9/1/2020)... GLENDALE, Calif. (PRWEB) , ... September 01, 2020 ... ... opened a new practice in Glendale. While the office will be ... procedures as breast augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons ... biomedical engineers from Carnegie Mellon University (CMU) to develop a new heart monitoring ... undergone open heart surgery. , The AGH/CMU team was recently awarded a “Trailblazer” ...
(Date:8/31/2020)... N.J. (PRWEB) , ... August 31, 2020 , ... ... leading cloud-based business management solution for chiropractors, announced today the launch of its ... healthcare professionals can start running their virtual practice in under 90 seconds. ...
(Date:8/31/2020)... , ... August 31, 2020 , ... In an effort ... Loop is donating 10 percent of each hotel room booked with a special ... of Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer Awareness Month. ... any other cancer of the female reproductive system. The American Cancer Society estimates ... 14,000 women will die from this disease. Throughout the month of September, Women’s ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... of primary care medical centers in Florida and San Antonio is happy to ... South Texas medical centers. , In this capacity he will serve as community ...
(Date:8/27/2020)... ... ... flu season is right round the corner and the risk of getting caught by influenza ... it begins to harbor its effects on us. Already with the sudden outbreak of COVID ... our lives. Hence it has become even more relevant to keep oneself immune from any ...
Breaking Medicine Technology:
Cached News: