New horizons, treatments in anticancer chemistry

proach to blocking tumor formation: The enzyme farnesyl protein transferase (FTPase) processes an important chemical involved in tumor formation. Researchers have developed compounds that block FTPase, resulting in decreased tumor formation in preclinical models. Some of these compounds, which are expected to have few side effects, are currently undergoing human clinical trials. (J.B. Gibbs, Ph.D., Merck Research Laboratories, West Point, Penn., MEDI 292, Tuesday, March 28, 8:30 a.m.; Arthur G. Taveras, Schering-Plough Research Institute, Kenilworth, N.J, MEDI 293, Tuesday, March 28, 9:10 a.m.; J.T. Hunt, Bristol-Myers Squibb, Princeton, N.J, MEDI 294, Tuesday, March 28, 9:50 a.m. All presentations in the Moscone Convention Center, Rooms 130/131. See page 134 in the final program.)

  • Stopping runaway blood vessel growth: Angiogenesis is the development of new blood vessels. In cancer, this process becomes unregulated, leading to uncontrolled tumor growth and spread. Researchers have designed a synthetic compound that stops tumor cell growth by interfering with angiogenesis. The new compound is in preclinical studies. (Peter G. Ruminski, Ph.D., Searle Research and Development, Monsanto Company, North Chesterfield, Mo., MEDI 295, Tuesday, March 28, 10:30 a.m., Moscone Convention Center, Rooms 130/131. See page 134 in the final program.)


  • Contact: Charmayne Marsh
    American Chemical Society

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