HOME >> MEDICINE >> NEWS
New horizons of nerve repair

It's sticky, it's a gel, it comes in a tube, but this is no greasy kids' stuff. Rather, it's a novel delivery system for peripheral nerve regeneration that could have implications for successful stem cell delivery and spinal cord repair.

Shelly Sakiyama-Elbert, Ph.D., assistant professor of biomedical engineering at Washington University in St. Louis, has designed a system that employs a nerve guide tube filled with a gel containing growth factor proteins that stimulate nerve regeneration. Also part of the package are strategically placed sugars and peptides for binding in the gel matrix. The system has promoted peripheral nerve regeneration in preliminary rat studies.

The clinical Gold Standard for peripheral nerve regeneration involves taking a nerve from a donor site on the injured person's body and sewing the donor nerve in between the two ends of the injured nerve. Though the nerve is dead, it provides a pathway that can guide the regeneration of the injured nerve. This is problematic because it creates an injury to be addressed at the donor site, and there is a limit to the amount of donor tissue you can use from a patient. Furthermore, there is no guarantee that the donated nerve will come to life in a new site. Another alternative is the use of cadaver nerves, which runs a risk of rejection.

Sakiyama-Elbert, working with famed plastic surgeon Susan Mackinnon ,M.D., Syd. M. and Robert H. Shoenberg Professor of Surgery of the Washington University Medical School, places exogenous sticky material capable of binding growth factors throughout the gel, causing the growth factor proteins to remain in the gel for months because they keep tripping over the sticky material. These binding sites can be tuned according to how fast the drug needs to be released for successful regeneration. Timed release is a key component of her system, because a real limitation is having the proteins diffuse out in a day or two, which is the case with man
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
22-Jul-2002


Page: 1 2 3

Related medicine news :

1. New horizons in cortical cartography
2. New horizons, treatments in anticancer chemistry
3. Schepens scientists regenerate optic nerve for the first time
4. An implanted nerve stimulator helps drop foot sufferers walk faster and better
5. Engineers develop biowarfare sensing elements for future highly sensitive nerve-gas detectors
6. Drug treatment promising for halting Huntingtons-related nerve death
7. Wisconsin scientists grow critical nerve cells
8. Antibody treatment partially reverses nerve damage in Alzheimer disease
9. Antibiotics protect nerves in mice by turning on genes
10. New clue to nerve growth may help regeneration efforts
11. Replicating an eels nerve circuitry may aid paralyzed people

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the ... medical article to the newly revamped Cosmetic Town journal section, featuring ... transplant procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... CAESAREA, Israel and NEW YORK , Sept. ... company with mobile health and big data solutions, today announced that its ... today. Please check your local TV listings for when The Dr. Oz ... ... ninth season this month. ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
Breaking Medicine Technology:
Cached News: