New imaging method in development to show Alzheimer's p...( s the AD brain. The imaging is then d...)

New imaging method in development to show Alzheimer's progression

s the AD brain. The imaging is then done with single-photon computed tomography (SPECT) that relies on the detection of gamma particles emitted by the trace amounts of radioactive technetium probe.

"Our goal," Lansbury states, "is to prepare compounds that can cross the blood-brain barrier effectively and bind to brain amyloid, allowing its precise quantitation." In this paper, his group reports the synthesis of a group of compounds that have the solubility properties that are commonly associated with effective brain imaging agents. "Our compounds are also shown to effectively label amyloid plaques in tissue slices from postmortem AD brain," he adds.

"Studies are in progress to determine whether these compounds will reach the brain of a live animal, as suggested by their solubility properties, and bind brain amyloid. In addition, a novel series of analogs that is expected to have improved qualities for in vivo application have been synthesized and are also being tested in animals." A patent application, originally filed in 1996, is under review.

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Contact: Mary Stanik
m_stanik@acs.org
202-872-4065
American Chemical Society
5-Aug-1999

Page: 1 2
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