HOME >> MEDICINE >> NEWS
New quit strategy offers smokers more pleasure, less risk

LOS ANGELES--By targeting the enzyme that metabolizes nicotine, researchers at the University of Toronto have devised a new strategy to wean smokers from cigarettes.

"This principal is quite different than anything currently in use," said Edward M. Sellers, MD, lead investigator of a study presented during the annual meeting of the American Society for Clinical Pharmacology and Therapeutics. The presentation is part of a panel describing new findings in the metabolic aspects of smoking and drug abuse.

Sellers' research has focused on the cytochrome P450 2A6 enzyme, which metabolizes nicotine to its inactive byproduct cotinine and activates carcinogens in tobacco smoke. By inhibiting the action of the enzyme, more nicotine remains in the bloodstream and the pleasure smokers get from a cigarette lasts longer. As a result, smokers may light up less frequently. Blocking the enzyme also prevents activation of carcinogenic substances in tobacco smoke.

"Smoking is a regulated behavior," Sellers said. "People will not let their nicotine levels go beyond a certain amount. If they go up momentarily, smokers will take fewer or smaller puffs. That can be the first step to quitting." Most current smoking cessation methods reduce withdrawal symptoms by replacing nicotine via patches, gum, inhalers or vaporizers. The prescription drug Zyban is an anti-depressant approved for use as a stop-smoking aid.

In a study with 11 smokers, Sellers has demonstrated that the psoriasis drug methoxsalen is a potent enzyme inhibitor, capable of increasing blood levels of nicotine while reducing exhaled carbon monoxide. Little of the drug enters the bloodstream, reducing exposure to internal organs and other body tissue. Sellers cautions, however, that methoxsalen has not been approved for use in smoking cessation. More safety testing is needed, but the concept is very promising.

"In this research we know that if we inhibit the enzyme, if we find a new drug that do
'"/>

Contact: Kirk Monroe
202-789-8101
K-M Communications
14-Mar-2000


Page: 1 2

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Diagnosis of prions in patients should utilize novel strategy, team says
3. New mosquito control strategy proves successful against dengue fever
4. Pathogen-mimicking vaccine as strategy for cancer therapy
5. Vaccinating school children and high risk groups is best strategy for slowing flu transmission
6. Novel drug-antidote strategy provides greater control of drug action
7. Tony Blair launches UKs new global AIDS strategy
8. Small, frequent doses of caffeine best strategy for staying awake
9. New study: Small, frequent doses of caffeine best strategy for staying awake
10. New strategy aims to halve malaria deaths by 2010
11. Business strategy used to increase immunization rates in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2020)... ... February 11, 2020 , ... R3 Medical Training is now ... 2020 in Las Vegas. The training consists of thread lift placement on real patients ... , PDO thread lifts represent an excellent alternative currently for nonoperative facelift. The procedures ...
(Date:2/10/2020)... , ... February 10, 2020 , ... ... Health and Epidemiology Practice, has been elected president of the Society for ... she and her team develop and implement award-winning, research-driven Federal social marketing campaigns ...
(Date:2/10/2020)... SANTA BARBARA, Calif. (PRWEB) , ... ... ... Palette Life Sciences, Inc., a medical device company dedicated to assisting ... conditions and diseases, today announced the launch of the Solesta® Reimbursement Assistance ...
(Date:2/10/2020)... ... February 10, 2020 , ... American Family Care (AFC), ... aggressively expanding its healthcare network across New England. The first phase includes ... the fast-growing healthcare system. , AFC’s Founder and CEO, Dr. Bruce Irwin , ...
(Date:2/9/2020)... ... 09, 2020 , ... Kim A. Gorgens, Ph.D., ABPP is ... University of Denver. Since 2013, Dr. Gorgens and The Brain Injury Alliance of ... determined that 50-80% of the inmates in Denver County Jails have traumatic brain ...
Breaking Medicine News(10 mins):
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... A device ... called Hush Buddy -- a patented sleep training system for children, launching today ... their parents. , With the Hush Buddy Sleep System, getting a child to sleep ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... ... healthcare industry from cyberattacks. One way Alpine is securing healthcare is by working ... Medical devices range from external systems, such as drug infusion pumps or patient ...
(Date:2/7/2020)... ... February 07, 2020 , ... Isagenix International ... announced the grand prize winner of its 2020 U.S. IsaBody Challenge® at the ... Washington, was honored onstage in front of thousands of Isagenix independent distributors and ...
Breaking Medicine Technology:
Cached News: