New research expands understanding of treatment for ADHD

Although methylphenidate (Ritalin) is the most frequently prescribed drug for treating attention deficit hyperactivity disorder (ADHD), its mechanism of action and its effects on the human brain have been poorly understood.

In an article in the January 12 online issue of the Journal of Neuroscience, researchers have for the first time assessed the effects of therapeutic doses of oral Ritalin on the levels of dopamine in the human brain. Dopamine imbalances appear to be closely related to ADHD symptoms.

This research begins to explain how Ritalin works to treat ADHD, says NIDA Director Alan I. Leshner, Ph.D. And in doing so it helps us to better understand the biology of ADHD. Understanding this process can help doctors appropriately diagnose and treat children with the disorder and could eventually provide practitioners with a clearer framework for prescribing the medication.

ADHD is the most commonly diagnosed behavioral disorder in childhood. An estimated 3 to 5 percent of the general population suffers from the disorder, which is characterized by agitated behavior and an inability to focus on tasks.

Although previous research demonstrated that methylphenidate administered intravenously increases dopamine levels in the brain, this study is the first to assess the effects on dopamine levels when Ritalin is administered orally, the way most patients receive the drug.

A team of investigators from the Brookhaven National Laboratory in Upton, New York, and the University of New York at Stony Brook used positron emission tomography to confirm that administration of Ritalin resulted in increased dopamine levels in healthy, adult male subjects.

According to Dr. Nora D. Volkow, the lead investigator, Ritalin is a dopamine transmitter blocker and hence it amplifies [dopamine] release.One could therefore speculate that the amplification of weak dopamine signals in subjects with ADHD by [Ritalin] would enhance task-specific signaling, and improve at

Contact: Michelle Muth
NIH/National Institute on Drug Abuse

Page: 1 2

Related medicine news :

1. Public morally obliged to take part in scientific research, says leading ethicist
2. U of M researcher says Viagra may cause permanent vision loss in some men
3. Indiana University researchers closer to helping hearing-impaired using stem cells
4. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
5. RIT takes eye-tracking research to next level
6. UW research shows risk factors for relapse among health care professionals who abuse drugs
7. Protein that helps skin cancer spread identified by Stanford researchers
8. US life expectancy about to decline, researchers say
9. Ethical discussion should come before research
10. Philanthropist Paul F. Glenn launches labs for aging research at Harvard Medical School
11. Gene for age-related macular degeneration discovered by Yale researchers

Post Your Comments:

(Date:7/1/2020)... TAMPA, Fla. (PRWEB) , ... July 01, 2020 ... ... biotechnology LLC specializing in the clinical development of psychedelics and analogues, announces its ... years combined experience in natural product drug discovery, novel formulations, and as distinguished ...
(Date:6/28/2020)... ... 2020 , ... The Pool & Hot Tub Alliance (PHTA) ... ANSI/APSP/ICC-7 2013 American National Standard for Suction Entrapment Avoidance In Swimming Pools, Wading ... the PHTA-7 Standard Writing Committee (SWC) for Suction Entrapment Avoidance in Swimming Pools, ...
(Date:6/28/2020)... (PRWEB) , ... June 26, 2020 , ... ... Inland Detox, the Inland Empire’s premier residential addiction treatment center, proudly announces that ... that now includes special preparation for recovery in a world affected by Covid-19. ...
(Date:6/28/2020)... LEXINGTON, Mass. (PRWEB) , ... June 27, 2020 ... ... its FSHD Connect Classroom, the first online, full-day educational conference in the organization’s ... educational meeting for facioscapulohumeral muscular dystrophy (FSHD), which was cancelled this year due ...
(Date:6/25/2020)... ... June 25, 2020 , ... Denials Management, Inc. has just published ... steps when filing appeals for denials of mental health and substance use disorder (MH/SUD) ... about their appeal rights and explain the steps in the appeals process. Complimentary ...
Breaking Medicine News(10 mins):
(Date:6/24/2020)... ... June 24, 2020 , ... ... number of common questions on County Line Chiropractic’s YouTube channel. Dr. ... , County Line Chiropractic has six locations in the South Florida area, including ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... a leading provider of center-based, Applied Behavioral Analysis ("ABA") therapy, today announced ... provider in the greater-Indianapolis market. This acquisition will make Lighthouse Autism Center ...
(Date:6/19/2020)... ... June 19, 2020 , ... Food Equality Initiative ... individuals diagnosed with food allergies and celiac disease announced the first of the “ ... This webinar is scheduled for Friday, June 19, 2020, from 11:00, am EST - ...
Breaking Medicine Technology:
Cached News: