HOME >> MEDICINE >> NEWS
New studies show mixed results on epilepsy drugs and birth defects

e pregnancy occurs."

The bad news is about the drug valproic acid. One study monitored the rate of birth defects in infants whose mothers had taken valproic acid as their only epilepsy drug during the first trimester of pregnancy and were enrolled in the North American Antiepileptic Drug (AED) Pregnancy Registry. Of the 149 women in the study, there were 16 infants with birth defects, or 10.7 percent. The women taking valproic acid were nearly three times more likely to have an infant with a birth defect than women taking another epilepsy drug. They were more than seven times more likely to have an infant with a birth defect than women in the general population.

For the second study on valproic acid, British researchers recruited 163 mothers with epilepsy and their children and gave them a number of tests. A total of 249 children between the ages of 6 and 16 took the tests. The 41 children who were exposed to valproic acid during pregnancy were more likely to have low verbal IQ scores (average of 84) compared to other groups in the study, such as those exposed only to the drug phenytoin (average score of 99) or those not exposed to any epilepsy drug during pregnancy (average score of 92).

Those exposed to valproic acid were also more likely to have overall IQ scores in the extremely low, or mentally impaired, range. Two to three percent of the population would be expected to fall in this range. In the study, 22 percent of those exposed to valproic acid were in this range.

Penovich noted that maintaining effective epilepsy treatment during pregnancy is crucial. "Seizures can cause fetal distress, and the severe epilepsy state called status epilepticus where attacks occur in rapid succession may cause catastrophic damage to the brain of the fetus," she said. More studies must be done to understand how valproic acid works to affect fetal development. "Without good animal models, the mechanism for the abnormalities remains unknown," Penov
'"/>

Contact: Marilee Reu
mreu@aan.com
651-695-2789
American Academy of Neurology
21-Mar-2005


Page: 1 2 3

Related medicine news :

1. New studies suggest airborne SARS transmission is possible
2. Brain imaging studies investigate pain reduction by hypnosis
3. Impact of scientific advances on drug studies and membrane research to be explored
4. Two studies find evidence that sunlight may have beneficial influence on cancer
5. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
6. Animal studies show stem cells might make biological pacemaker
7. Infants, children prefer sounds over pictures and only slowly become visually oriented, studies find
8. New studies on Ritalin and Alzheimers Disease highlight ACNP Annual Meeting
9. Gender and sex hormones affect the brains pain response and more, according to new studies
10. Analysis of tamoxifen studies reveals slight increase of stroke risk
11. Imaging studies clarify brain changes associated with language deficits in autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... February 22, 2017 , ... Secure Exchange Solutions, the ... network of hospitals, health information exchanges, physicians and patients, announced today that SES ... 2015 Edition Health IT Module Certification via Drummond Group LLC, an Authorized Certification ...
(Date:2/22/2017)... Dallas, TX (PRWEB) , ... ... ... HCC Risk Adjustment solution leverages advanced data analytics to accurately understand each ... ensure proper reimbursement for a given population. This new solution helps transform ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Sideline Products ... the company met national TV host Tom Seay and his production crew. Tom ... favorite among equestrians around the world. Saddle Sidekicks will be featured on April ...
(Date:2/22/2017)... Beach, FL (PRWEB) , ... February 22, 2017 , ... ... Wrestling Legend Kurt Angle, is now available on the App Store and ... and award-winning mobile apps for the addiction and recovery industry, partnered with Angle to ...
(Date:2/22/2017)... ... February 22, 2017 , ... A product of digesting ... to derive a heart-protective benefit from eating soy foods, while others do not, a ... who are able to produce equol—a substance made by some types of “good” gut ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 The top ... are Olympus Corporation, Nikon Corporation, and Leica Microsystems. ... in the overall market in 2015. The oligopolistic ... through result-oriented research and development activities and mergers ... focus on expanding their business to emerging economies ...
(Date:2/22/2017)... India , February 22, 2017 Arthroscopy Devices Market Report, ... million in 2015 and is projected to reach $5,334 million by 2022, growing at ... two-fifths of the total market in 2015. Continue Reading ... ... ...
(Date:2/22/2017)... Feb. 22, 2017  Known for selling everyday ... the widow of prominent California ... know something else about the British conglomerate that makes ... by attempting to steal her late husband,s invention, business ... operated by Dr. Gilbert until his violent death in ...
Breaking Medicine Technology:
Cached News: