New studies show mixed results on epilepsy drugs and birth defects

e pregnancy occurs."

The bad news is about the drug valproic acid. One study monitored the rate of birth defects in infants whose mothers had taken valproic acid as their only epilepsy drug during the first trimester of pregnancy and were enrolled in the North American Antiepileptic Drug (AED) Pregnancy Registry. Of the 149 women in the study, there were 16 infants with birth defects, or 10.7 percent. The women taking valproic acid were nearly three times more likely to have an infant with a birth defect than women taking another epilepsy drug. They were more than seven times more likely to have an infant with a birth defect than women in the general population.

For the second study on valproic acid, British researchers recruited 163 mothers with epilepsy and their children and gave them a number of tests. A total of 249 children between the ages of 6 and 16 took the tests. The 41 children who were exposed to valproic acid during pregnancy were more likely to have low verbal IQ scores (average of 84) compared to other groups in the study, such as those exposed only to the drug phenytoin (average score of 99) or those not exposed to any epilepsy drug during pregnancy (average score of 92).

Those exposed to valproic acid were also more likely to have overall IQ scores in the extremely low, or mentally impaired, range. Two to three percent of the population would be expected to fall in this range. In the study, 22 percent of those exposed to valproic acid were in this range.

Penovich noted that maintaining effective epilepsy treatment during pregnancy is crucial. "Seizures can cause fetal distress, and the severe epilepsy state called status epilepticus where attacks occur in rapid succession may cause catastrophic damage to the brain of the fetus," she said. More studies must be done to understand how valproic acid works to affect fetal development. "Without good animal models, the mechanism for the abnormalities remains unknown," Penov

Contact: Marilee Reu
American Academy of Neurology

Page: 1 2 3

Related medicine news :

1. New studies suggest airborne SARS transmission is possible
2. Brain imaging studies investigate pain reduction by hypnosis
3. Impact of scientific advances on drug studies and membrane research to be explored
4. Two studies find evidence that sunlight may have beneficial influence on cancer
5. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
6. Animal studies show stem cells might make biological pacemaker
7. Infants, children prefer sounds over pictures and only slowly become visually oriented, studies find
8. New studies on Ritalin and Alzheimers Disease highlight ACNP Annual Meeting
9. Gender and sex hormones affect the brains pain response and more, according to new studies
10. Analysis of tamoxifen studies reveals slight increase of stroke risk
11. Imaging studies clarify brain changes associated with language deficits in autism

Post Your Comments:

(Date:11/29/2015)... (PRWEB) , ... November 29, 2015 , ... Khanna Vision ... Board of Ophthalmology on November 25th 2015. Peer Certification by the Board ... of his specialty. Certification in Ophthalmology is first obtained after the completion of three ...
(Date:11/29/2015)... IL (PRWEB) , ... November 29, 2015 , ... Effective ... Target.com. In addition starting on Black Friday Target is offering a “Buy One ... This is a rare opportunity to purchase IguanaMed at a discounted price. ...
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Trying to ... has created the COUCH BUDDY. "I conceived of this design due to personal experience ... for couch users. It promotes relaxation and convenience, as well as increases support. It ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved around ... help protect a patient’s overall health. The talk stressed the link between periodontal disease ...
(Date:11/27/2015)... , ... November 27, 2015 , ... A team of ... ways to treat it. Surviving Mesothelioma has just posted the findings on the website. ... Hospital Zurich analyzed the cases of 136 mesothelioma patients who were treated with chemotherapy ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 3D bioprinting market ... to a new report by Grand View Research Inc. Rising ... which demands kidney transplantation is expected to boost the market ... for organ transplantation. --> 3D bioprinting market ... to a new report by Grand View Research Inc. Rising ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> http://www.researchandmarkets.com/research/6ln9lq/2016_future ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... India , November 26, 2015 ... --> RnRMarketResearch.com adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... http://www.rnrmarketresearch.com/global-repaglinide-industry-2015-market-research-report-market-report.html . ...
Breaking Medicine Technology:
Cached News: