HOME >> MEDICINE >> NEWS
New study: Small, frequent doses of caffeine best strategy for staying awake

Boston, MA - May 11, 2004 - Caffeine is the world's most widely-used stimulant yet, scientists still do not know exactly how it staves off sleep. Researchers at Brigham and Women's Hospital, Harvard Medical School and other institutions have now discovered that caffeine works by thwarting one of two interacting physiological systems that govern the human sleep-wake cycle. The researchers, who report their findings in the May issue of the journal Sleep, propose a novel regimen, consisting of frequent low doses of caffeine, to help shift workers, medical residents, truck drivers, and others who need to stay awake get a bigger boost from their tea or coffee.

" Most people take a huge jolt of coffee in the morning to jumpstart their day-they get the super grande latte from Starbucks," said Charles Czeisler, who was recently appointed the Frank Baldino Jr. PhD professor of sleep medicine at Harvard Medical School. "Their caffeine levels soar only to fall as the day progresses in the face of rising sleepiness. They might be better off taking much smaller more frequent doses of caffeine, equivalent to a quarter of a cup of coffee, as the day wears on."

Though many studies have measured caffeine's sleep-averting effects, most do not take into account that sleep is governed by two opposing but interacting processes. The circadian system promotes sleep rhythmically-an internal clock releases melatonin and other hormones in a cyclical fashion. In contrast, the homeostatic system drives sleep appetitively-it builds the longer one is awake. If the two drives worked together, the drive for sleep would be overwhelming. As it turns out, they oppose one another.

Czeisler, who also leads the Division of Sleep Medicine at HMS, and his colleagues had reason to suspect that caffeine might be working to blunt the homeostatic system. For one thing, caffeine is thought to block the receptor for adenosine, a critical chemical messenger involved in the homeostatic dri
'"/>

Contact: Judith Montminy or Misia Landau
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
11-May-2004


Page: 1 2 3 4

Related medicine news :

1. UNC study: Most N.C. family practitioners engage in unrecognized community service
2. UCLA study: Nearly a third of drug ads in medical journals contain no references for medical claims
3. More homeless mentally ill than expected according to UCSD study: Interventions urged
4. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
5. Mouse study: Signal overload in Alzheimer brains
6. OHSU study: Testosterone deprivation makes men forget
7. Mayo Clinic led study: Minimally invasive surgery safe, effective for patients with colon cancer
8. OHSU study: Rate of brain volume loss predicts dementia
9. Major study: Bioartificial liver reduces mortality by 44 percent in acute liver-failure patients
10. National study: Health care access for poor children improves, but gap in care for uninsured grows
11. UCSF study: Pediatricians judgment often better than clinical guidelines for treating infant fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in ... 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced ... 2017. , The annual award competition recognizes editorial and design excellence across a range ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology:
Cached News: