HOME >> MEDICINE >> NEWS
New study: Small, frequent doses of caffeine best strategy for staying awake

Boston, MA - May 11, 2004 - Caffeine is the world's most widely-used stimulant yet, scientists still do not know exactly how it staves off sleep. Researchers at Brigham and Women's Hospital, Harvard Medical School and other institutions have now discovered that caffeine works by thwarting one of two interacting physiological systems that govern the human sleep-wake cycle. The researchers, who report their findings in the May issue of the journal Sleep, propose a novel regimen, consisting of frequent low doses of caffeine, to help shift workers, medical residents, truck drivers, and others who need to stay awake get a bigger boost from their tea or coffee.

" Most people take a huge jolt of coffee in the morning to jumpstart their day-they get the super grande latte from Starbucks," said Charles Czeisler, who was recently appointed the Frank Baldino Jr. PhD professor of sleep medicine at Harvard Medical School. "Their caffeine levels soar only to fall as the day progresses in the face of rising sleepiness. They might be better off taking much smaller more frequent doses of caffeine, equivalent to a quarter of a cup of coffee, as the day wears on."

Though many studies have measured caffeine's sleep-averting effects, most do not take into account that sleep is governed by two opposing but interacting processes. The circadian system promotes sleep rhythmically-an internal clock releases melatonin and other hormones in a cyclical fashion. In contrast, the homeostatic system drives sleep appetitively-it builds the longer one is awake. If the two drives worked together, the drive for sleep would be overwhelming. As it turns out, they oppose one another.

Czeisler, who also leads the Division of Sleep Medicine at HMS, and his colleagues had reason to suspect that caffeine might be working to blunt the homeostatic system. For one thing, caffeine is thought to block the receptor for adenosine, a critical chemical messenger involved in the homeostatic dri
'"/>

Contact: Judith Montminy or Misia Landau
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
11-May-2004


Page: 1 2 3 4

Related medicine news :

1. UNC study: Most N.C. family practitioners engage in unrecognized community service
2. UCLA study: Nearly a third of drug ads in medical journals contain no references for medical claims
3. More homeless mentally ill than expected according to UCSD study: Interventions urged
4. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
5. Mouse study: Signal overload in Alzheimer brains
6. OHSU study: Testosterone deprivation makes men forget
7. Mayo Clinic led study: Minimally invasive surgery safe, effective for patients with colon cancer
8. OHSU study: Rate of brain volume loss predicts dementia
9. Major study: Bioartificial liver reduces mortality by 44 percent in acute liver-failure patients
10. National study: Health care access for poor children improves, but gap in care for uninsured grows
11. UCSF study: Pediatricians judgment often better than clinical guidelines for treating infant fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/18/2017)... (PRWEB) , ... February 17, 2017 , ... ... leading source of disruptive innovation in the industry, according to the recent NEJM ... are based on surveys of the NEJM Catalyst Insights Council, a qualified group ...
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, ... , Beverly Hills plastic surgeon Dr. Glenn Vallecillos experiments SculpSure, the ... says, "Traditionally, plastic surgery has been centered around that idea that to achieve ...
(Date:2/18/2017)... Viejo, CA (PRWEB) , ... February 18, 2017 ... ... animating paragraph presets. Use Pixel Film Studios ’ ProParagraph Fashion Volume ... descriptions, and so many other applications. Users can pick and choose from ...
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a ... Davidson, NC. Dr. Brian Seese leads the practice as a skilled and highly credentialed ... roof. Smiles by Seese serves patients of all ages with excellence in general, restorative, ...
(Date:2/17/2017)... CA (PRWEB) , ... February 17, 2017 , ... ... focus on foundational and sustainable systems change designed to further positively impact the ... “The Board of Trustees has long considered it our duty to seriously consider ...
Breaking Medicine News(10 mins):
(Date:2/18/2017)... , Feb. 17, 2017  Pharmaceutical companies have long used ... either in development or already on the market.   ... pharma industry to alter how it manages advisory board meetings. ... Best Practices, LLC conducted a new study focused on key ... ...
(Date:2/17/2017)... , Feb. 17, 2017  Ethicon, Inc. ... Medical, Inc., a privately held medical device company ... Reflux Management System, a novel minimally invasive device ... of Torax Medical will enable Ethicon to offer ... anatomy-altering laparoscopic Nissen fundoplication surgical procedure. 1 ...
(Date:2/17/2017)... Arvinas LLC, a private biotechnology company creating ... today announced the presentation of new preclinical data on ... session at the American Society of Clinical Oncology 2017 ... FL. "The new data ... potential of PROTACs to drive durable and robust responses ...
Breaking Medicine Technology:
Cached News: