HOME >> MEDICINE >> NEWS
New study in 'Nature' demonstrates protection against cell death during heart attack

CINCINNATI -- A new study, conducted at Cincinnati Children's Hospital Medical Center and published in the journal Nature, has uncovered a fundamental mechanism by which cells die a finding that could quickly lead to improved emergency treatments for heart attack and stroke.

The Cincinnati Children's researchers discovered that blocking a particular protein in mice protects the heart from injury due to loss of blood flow during a heart attack. Moreover, drugs already exist that block this protein cyclophilin D but they have never been used in actual patient care, partially because data didn't exist until now to prove they would work, according to Jeff Molkentin, Ph.D., a researcher at Cincinnati Children's and the study's senior author.

Cyclophilin D resides within the mitochondria of a cell. The mitochondria are the power plants of a cell and are responsible for the majority of energy production. When mitochondria do not function properly, such as when tissue is deprived of oxygen, cells begin to die through a process involving rupture of the mitochondria. When cyclophilin D is deleted from the mitochondria, however, a cell's ability to die is blocked, according to Dr. Molkentin.

"When a person comes to a hospital and it's realized that he or she is having a heart attack or stroke, one of the first things done is to re-establish blood flow," says Dr. Molkentin. "At this point, cells have not yet died. But when flow is re-established there is a huge burst of reactive oxygen, and that's when cells die. We hypothesize that if, at the same time you re-establish flow you infuse a cyclophilin D inhibitor, you might profoundly affect the heart or brain and, presumably, protect it."

A class of drugs already exists that blocks cyclophilin D. The most well known one is cyclosporine, a drug used to prevent rejection in organ transplantation. Cyclosporin has a downside, however. In addition to blocking cyclophilin D, it also b
'"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
30-Mar-2005


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. UCSF study offers insight into human circadian rhythms
6. International breast cancer prevention study launches in the United States and Canada
7. UW study shows blacks and Latinos are more satisfied with physicians of the same race
8. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
9. Advertising by academic medical centers may risk eroding public trust, says study
10. Fat may promote inflammation, new study suggests
11. Bullying among sixth graders a daily occurrence, UCLA study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... ... 2019 , ... Mount Sinai Health System is hosting a ... Nations Staff Recreation Council in support of the Helen Sawaya Fund, a philanthropic ... art, massage, and pet therapies to increase the comfort and emotional and mental ...
(Date:1/10/2019)... ... ... The Karis Group, an Austin, Texas based company, announced today that it has ... Mr. Jiwa succeeds the past Chief Executive Officer, Mike Martin, who retired from ... as part of an orderly succession plan and transition of leadership at the 22-year ...
(Date:1/8/2019)... ... ... West 10th Dental in New York, NY is pleased to announce the launch ... founder of West 10th Dental, "We want our patients to know that we are, ... up with the latest in technology as dentistry changes, and by making ourselves always ...
(Date:1/8/2019)... (PRWEB) , ... January 08, 2019 , ... In Partnership ... provide free dental services for low-income, underinsured individuals in Las Vegas, NV on February ... x-rays, fillings, cleanings and extractions. For more information, please visit the Smiles for Everyone ...
(Date:1/7/2019)... , ... January 07, 2019 , ... ... Course is now a candidate for accreditation from the American Society of ... nationwide. The organization’s 45,000 members include pharmacists, student pharmacists and pharmacy technicians. , ...
Breaking Medicine News(10 mins):
(Date:1/11/2019)... ... ... According to research, acupuncture can quickly and effectively treat sinusitis, allergy, and asthma ... the respiratory treatment they need at its Houston clinic. , “We don’t just treat ... Acupuncture and Chinese Medicine can treat a wide range of conditions,” said Sylvia He, ...
(Date:1/10/2019)... (PRWEB) , ... January 10, 2019 , ... ... to introduce the new A-Series Advantage Anesthesia Delivery platform, providing a modular, state-of-the-art ... A7 Advantage systems, enabling Mindray to continue its unwavering commitment to perioperative care. ...
(Date:1/8/2019)... ... January 08, 2019 , ... University Hospitals ... UroLift® Center of Excellence. The designation recognizes that Dr. Jaeger has achieved a ... commitment to exemplary care for men suffering from symptoms associated with benign prostatic ...
Breaking Medicine Technology:
Cached News: