HOME >> MEDICINE >> NEWS
New study in 'Nature' demonstrates protection against cell death during heart attack

CINCINNATI -- A new study, conducted at Cincinnati Children's Hospital Medical Center and published in the journal Nature, has uncovered a fundamental mechanism by which cells die a finding that could quickly lead to improved emergency treatments for heart attack and stroke.

The Cincinnati Children's researchers discovered that blocking a particular protein in mice protects the heart from injury due to loss of blood flow during a heart attack. Moreover, drugs already exist that block this protein cyclophilin D but they have never been used in actual patient care, partially because data didn't exist until now to prove they would work, according to Jeff Molkentin, Ph.D., a researcher at Cincinnati Children's and the study's senior author.

Cyclophilin D resides within the mitochondria of a cell. The mitochondria are the power plants of a cell and are responsible for the majority of energy production. When mitochondria do not function properly, such as when tissue is deprived of oxygen, cells begin to die through a process involving rupture of the mitochondria. When cyclophilin D is deleted from the mitochondria, however, a cell's ability to die is blocked, according to Dr. Molkentin.

"When a person comes to a hospital and it's realized that he or she is having a heart attack or stroke, one of the first things done is to re-establish blood flow," says Dr. Molkentin. "At this point, cells have not yet died. But when flow is re-established there is a huge burst of reactive oxygen, and that's when cells die. We hypothesize that if, at the same time you re-establish flow you infuse a cyclophilin D inhibitor, you might profoundly affect the heart or brain and, presumably, protect it."

A class of drugs already exists that blocks cyclophilin D. The most well known one is cyclosporine, a drug used to prevent rejection in organ transplantation. Cyclosporin has a downside, however. In addition to blocking cyclophilin D, it also b
'"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
30-Mar-2005


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. UCSF study offers insight into human circadian rhythms
6. International breast cancer prevention study launches in the United States and Canada
7. UW study shows blacks and Latinos are more satisfied with physicians of the same race
8. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
9. Advertising by academic medical centers may risk eroding public trust, says study
10. Fat may promote inflammation, new study suggests
11. Bullying among sixth graders a daily occurrence, UCLA study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... ... , ... METAvivor Research and Support Inc., a non-profit organization dedicated to funding ... Stampede campaign. The campaign will commence with two days of action and education on ... camp, a march, a Die-In (hosted by partner MET-UP), and visits with Congressional offices. ...
(Date:10/8/2019)... ... October 08, 2019 , ... The ... a Digital Health Awards 1st Round (Top Ten) Finalist in its Best ... to select companies that promote faster, better, more cost-effective healthcare by improving outcomes ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... dentistry techniques, has recently attended an advanced Level III training in Cagliari, Italy, ... dentistry. The training took place September 16-19, 2019 at the Sardinia Dental Teaching ...
(Date:10/8/2019)... TORONTO (PRWEB) , ... October 08, 2019 , ... ... at a cost of $28 billion per year, are reproducible. Rigor in bioanalytical ... are increasingly outsourced (by some estimates, more than half of the time) and ...
(Date:10/8/2019)... ... October 08, 2019 , ... U.S. Oral ... that exclusively serves premier oral and maxillofacial surgeons – has formed a new ... practice with two locations near Knoxville, Tennessee. The partnership is USOSM’s first in ...
Breaking Medicine News(10 mins):
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... Fresno resident ... Donate Life Rose Parade® Float living donor honoree. Regina will walk alongside the float, ... Day. , Regina, a retired nurse and attorney, became a living organ donor in ...
(Date:10/8/2019)... ... , ... Four things to know: , 1. The Hive™ ALIF interbody contains ... the lattice core. , 2. The Soft Titanium® lattice of HD LifeSciences ... growth throughout the implant. , 3. The Hive™ ALIF device can hold over 5cc ...
(Date:10/8/2019)... ... October 08, 2019 , ... Corteva Agriscience ... range of novel, microbial-based crop protection products. , Under the agreement, MicroMGx will ... points. In a first for the agriculture industry, Corteva will use those starting ...
Breaking Medicine Technology:
Cached News: