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New study in 'Nature' demonstrates protection against cell death during heart attack

locks calcineurin, an agent that protects the immune system. Fortunately, there are so-called analogs of cyclosporin that block cyclophilin D but do not affect the immune system.

While these drugs have not yet been tested in humans, there have been numerous studies indicating they protect against stroke in many different animal models, according to Dr. Molkentin, a scientist in the division of Molecular Cardiovascular Biology at Cincinnati Children's.

"Our study suggests that these drugs should be re-evaluated for injury related to loss of blood flow," says Dr. Molkentin. "Although our study was in a mouse model and looked at the heart, studies in cell culture indicate similar benefits when blood flow causes injury to the brain, kidney and liver. The data support clinical trials. Cyclosporin already has been tested in humans and has been well-tolerated acutely."


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Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
30-Mar-2005


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