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New study in mice shows promise for vaccine to prevent plaque buildup

LOS ANGELES (EMBARGOED UNTIL MARCH 18, 2002 AT 3 P.M. EASTERN) Cardiac researchers at Cedars-Sinai Medical Center, working in collaboration with Swedish investigators, have developed a novel vaccine to prevent plaque buildup in genetically engineered mice with high cholesterol levels.

Abstracts of their results are being presented from 3 to 5 p.m. Monday, March 18 at the American College of Cardiologys annual scientific session in Atlanta.

The vaccine consists of synthetic peptides (compounds that make up proteins) that resemble the structure of certain portions of the major protein component (Apo B100) of the bad type of cholesterol (low-density lipoprotein or LDL). Using this peptide-based vaccine, both the Cedars-Sinai group and the Swedish group have shown 60 to 70 percent less arterial plaque formation in mice with high cholesterol levels.


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Contact: Sandra Van
sandy@vancommunications.com
1-800-880-2397
Cedars-Sinai Medical Center
18-Mar-2002


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