HOME >> MEDICINE >> NEWS
New study shows how mad cow prions hitch a ride into intestine

A new study from the Department of Pathology at Case Western Reserve University School of Medicine shows that the infectious version of prion proteins, the main culprits behind the human form of mad cow disease or variant Creutzfeldt-Jakob Disease (vCJD), are not destroyed by digestive enzymes found in the stomach. Furthermore, the study finds that the infectious prion proteins, also known as prions, cross the normally stringent intestinal barrier by riding piggyback on ferritin, a protein normally absorbed by the intestine and abundantly present in a typical meat dish. The study appears in the Dec. 15 issue of the Journal of Neuroscience.

Prions are a modified form of normal proteins, the prion proteins, which become infectious and accumulate in the nervous system causing fatal neurodegenerative disease. Variant CJD results from eating contaminated beef products from cattle infected with mad cow disease. To date, 155 cases of confirmed and probable vCJD in the world have been reported, and it is unclear how many others are carrying the infection.

According to the study's senior author Neena Singh, M.D., Ph.D., associate professor of pathology, little is known about the mechanism by which prions cross the human intestinal barrier, which can be a particularly difficult obstacle to cross.

"The mad cow epidemic is far from over, and the continuous spread of a similar prion disease in the deer and elk population in the U.S. raises serious public health concerns," said Singh. "It is therefore essential to understand how this disease is transmitted from one species to another, especially in the case of humans where the infectious prions survive through stages of cooking and digestion."

Using brain tissues infected with the spontaneously occurring version of CJD which is also caused by prions, the researchers simulated the human digestive process by subjecting the tissue to sequential treatment with digestive fluids as found in the
'"/>

Contact: George Stamatis
George.Stamatis@case.edu
216-368-3635
Case Western Reserve University
14-Dec-2004


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New study shows how mad cow prions hitch ride into intestine

(Date:9/3/2015)... Fullerton, Calif. (PRWEB) , ... September 03, 2015 , ... ... in Fullerton, where innovative medicine is the norm not the exception. , St. Jude ... and the American Heart Association/American Stroke Association, making it one of only 10 hospitals ...
(Date:9/3/2015)... New York (PRWEB) , ... September 03, 2015 , ... ... Do”. William Mattar, Esq. believes this does not stop at any certain demographic ... captioning to its newly produced one-minute, thirty-, fifteen- and ten-second TV commercials. , The ...
(Date:9/3/2015)... TX (PRWEB) , ... September 03, 2015 , ... ... pre-conference workshops included in Patient Experience Conference 2016, to be held April 13-15 ... non-provider or vendor hosted event bringing together the collective voices of healthcare leaders, ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization dedicated ... Product Development Group to manufacture a long-lasting reusable diaper for warm weather climates ... to bring 600 DriButts Diapers to rural areas of Haiti during a trip ...
(Date:9/3/2015)... ... ... Real Time Pain Relief (RTPR), makers of the popular rub-on pain ... an official endorsement deal with the company. Originally from New South Wales, Australia, Mason ... 15. He is an Australian bull riding champion, following in his uncles’ footsteps in ...
Breaking Medicine News(10 mins):Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 3Health News:Law Firm Focused on “Helping People” Continues to Expand on Vision 2Health News:Patient Experience Conference 2016 Program Announced by The Beryl Institute 2Health News:Patient Experience Conference 2016 Program Announced by The Beryl Institute 3Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Real Time Pain Relief Sponsors the Talented PBR Bull Rider from Down Under - David Mason 2Health News:Real Time Pain Relief Sponsors the Talented PBR Bull Rider from Down Under - David Mason 3
(Date:9/3/2015)... , Sept. 3, 2015 This Defibrillators are ... save millions of lives across globe. This report provides ... Kingdom of Saudi Arabia . Stakeholders for this ... government agencies and regulatory bodies. The Saudi ... two perspectives: by products and by end users. In ...
(Date:9/3/2015)... MENLO PARK, Calif. , Sept. 3, 2015 /PRNewswire/ ... medical device company that is providing innovative evidence-based solutions ... its management will be presenting at the Morgan Stanley ... New York City.  Nevro management is ... will be accessible via a live audio webcast, accessible ...
(Date:9/3/2015)... , Sept. 3, 2015  Ascendis ... clinical stage biotechnology company that applies its ... medical needs, today announced plans to present ... Wells Fargo Healthcare Conference in BostonDate: , ... , Bank of America Merrill Lynch Global ...
Breaking Medicine Technology:Saudi Arabia Defibrillators Market: & Advanced Life Support Defibrillators; End Users; Industry Analysis, Size, Volume, Growth, Trends and Forecast 2014 - 2020 2Ascendis Pharma A/S to Present at Three Upcoming Investor Conferences 2
Cached News: