HOME >> MEDICINE >> NEWS
New study shows how mad cow prions hitch a ride into intestine

A new study from the Department of Pathology at Case Western Reserve University School of Medicine shows that the infectious version of prion proteins, the main culprits behind the human form of mad cow disease or variant Creutzfeldt-Jakob Disease (vCJD), are not destroyed by digestive enzymes found in the stomach. Furthermore, the study finds that the infectious prion proteins, also known as prions, cross the normally stringent intestinal barrier by riding piggyback on ferritin, a protein normally absorbed by the intestine and abundantly present in a typical meat dish. The study appears in the Dec. 15 issue of the Journal of Neuroscience.

Prions are a modified form of normal proteins, the prion proteins, which become infectious and accumulate in the nervous system causing fatal neurodegenerative disease. Variant CJD results from eating contaminated beef products from cattle infected with mad cow disease. To date, 155 cases of confirmed and probable vCJD in the world have been reported, and it is unclear how many others are carrying the infection.

According to the study's senior author Neena Singh, M.D., Ph.D., associate professor of pathology, little is known about the mechanism by which prions cross the human intestinal barrier, which can be a particularly difficult obstacle to cross.

"The mad cow epidemic is far from over, and the continuous spread of a similar prion disease in the deer and elk population in the U.S. raises serious public health concerns," said Singh. "It is therefore essential to understand how this disease is transmitted from one species to another, especially in the case of humans where the infectious prions survive through stages of cooking and digestion."

Using brain tissues infected with the spontaneously occurring version of CJD which is also caused by prions, the researchers simulated the human digestive process by subjecting the tissue to sequential treatment with digestive fluids as found in the
'"/>

Contact: George Stamatis
George.Stamatis@case.edu
216-368-3635
Case Western Reserve University
14-Dec-2004


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New study shows how mad cow prions hitch ride into intestine

(Date:7/28/2015)... ... July 28, 2015 , ... VAZATA, a full service cloud ... presence to support their rapidly growing business. , Headquarted in Dallas, Texas, HeartPlace, ... Dallas/Fort Worth area for almost 50 years. HeartPlace is recognized as an innovator ...
(Date:7/28/2015)... ... ... Advanced Fertility Center of Texas (AFCT) has hosted the EMBCOL office ... a Reproductive Laboratory Director at AFCT, was one of the founders of EMBCOL and ... who is credited with the discovery of intra-cytoplasmic sperm injection (ICSI) , which ...
(Date:7/28/2015)... ... July 28, 2015 , ... Intellitec Solutions has been ... annual ranking of Value Added Resellers of ERP Software is a look at the ... with. This honor represents the second such award in 2015 for Intellitec Solutions, following ...
(Date:7/28/2015)... ... July 28, 2015 , ... Nurses across all settings increasingly ... to 57 million Americans may need mental health services (SAMHSA, 2013) and the implementation ... health RNs are one of the largest workforces who provide care to persons ...
(Date:7/28/2015)... , ... July 28, 2015 , ... Scientel ... NoSQL Now! Conference, August 18-20 at the McHenry Convention Center in San Jose, ... in booth #104. , Scientel’s presentation on Multi-Modeling and the industry’s first polymorphic database ...
Breaking Medicine News(10 mins):Health News:HeartPlace Announces Cloud Expansion with VAZATA 2Health News:HeartPlace Announces Cloud Expansion with VAZATA 3Health News:Advanced Fertility Center of Texas Is Proud to Announce That Our Lab Director Has Been Re-elected as The American College of Embryology President 2Health News:Intellitec Solutions Named by Accounting Today as Top 100 Value Added Reseller 2Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 2Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 3Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 4Health News:Scientel Selected to Present at 2015 NoSQLNow! Conference, San Jose August 18-20 2Health News:Scientel Selected to Present at 2015 NoSQLNow! Conference, San Jose August 18-20 3
(Date:7/28/2015)... WESTFORD, Mass., July 28, 2015   Cynosure, ... manufactures and markets medical devices for aesthetic procedures ... results for the three months ended June 30, ... another quarter of double-digit growth, as revenues increased ... said Cynosure Chief Executive Officer Michael Davin. "While ...
(Date:7/28/2015)... , July 28, 2015  Today, Sekisui Diagnostics announces ... affordable and efficient instrument, with a broad menu of ... benefits to the physicians, office or hospital laboratory. ... to 580 tests/hour with ISE, 72 patient sample on-board ... 36 onboard assays (+3 ISE) to meet the testing ...
(Date:7/28/2015)... Baebies, Inc. today announced the completion of ... oversubscribed round of financing included key investors Rex Health ... Capital, Triad, LLC, the Duke Angel Network and a ... Advanced Liquid Logic,s (ALL) former investors including Charleston Angel ... "Rex is pleased to support this promising young ...
Breaking Medicine Technology:Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 2Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 3Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 4Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 5Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 6Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 7Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 8Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 9Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 10Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 11Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 12Cynosure Announces Second-Quarter 2015 Results; Record Revenue of $83.7 Million, Up 15 Percent from Prior Year 13Sekisui Diagnostics Announces Launch of SK500 Clinical Chemistry System for US Laboratories 2Baebies, Inc. Raises $13 Million in Oversubscribed Round of Financing 2
Cached News: