HOME >> MEDICINE >> NEWS
New study shows ropinirole slows the loss of dopamine function in Parkinsons disease

Researchers at Emory University and a group of international collaborators, using positron emission tomography (PET) brain imaging, have determined that a relatively new drug slows the loss of dopamine function in early stages of Parkinsons disease (PD) compared with an older, more commonly used drug.

Investigators say the drug ropinirole (brand name ReQuip ) slows the loss of dopamine, a neurotransmitter produced by neurons in the brain that is found in steadily decreasing amounts as the disease progresses, in a more effective manner than levodopa (brand name Sinemet ).

In this trial, the progression of the loss of dopamine function was slowed by over 30 percent in participants taking ropinirole as compared with participants in a comparable stage of the disease taking levodopa.

Three-dimensional PET scans were taken before and after the study to show the level of dopamine loss in the brain, which can be inferred from a radioactive marker whose uptake by neurons is measured in PET imaging.

This multi-site, international trial is called "Requip as EArly therapy versus L-dopa", or the REAL-PET study. Emory University, under the guidance of Ray Watts, M.D., professor of neurology, Emory University School of Medicine, led the American sites, recruiting the most patients worldwide in the study.

Dr. Watts and collaborators will present their findings at the American Academy of Neurology 54th Annual Meeting in Denver, Colo., on Tuesday, April 16.

"We are really pleased with the outcome of this trial because it is one of the first of its kind to demonstrate slowing of the rate of loss of dopamine function in PD patients," Dr. Watts says. "It is also one of the first studies designed to use PET imaging in PD patients to differentiate how two different therapies (ropinirole vs. levodopa) affect progression of the loss of dopamine function."

Participants in this double-blind, two-year study had been diagnosed withi
'"/>

Contact: Janet Christenbury
jmchris@emory.edu
404-727-8599
Emory University Health Sciences Center
16-Apr-2002


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/16/2017)... Angeles, California (PRWEB) , ... August 16, 2017 , ... An August 3rd article ... that was the subject of a report in JAMA (the Journal of the American Medical ... above 50 were able to achieve BMIs under 30, when compared to patients with lower ...
(Date:8/16/2017)... FL (PRWEB) , ... August 16, 2017 , ... ... standardized product data and images announced today that it was acquired by Advantage ... Industry’s solution for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, ...
(Date:8/16/2017)... ... August 16, 2017 , ... In 1987, ... celebrate 30 years in business this year, and they’re marking the milestone by ... to serve their patients. , It stands to reason that, given the ...
(Date:8/16/2017)... ... August 16, 2017 , ... Modern Consulting Insurance & ... program. Partnering once again with Boys & Girls Clubs of Greater Kansas City, ... area’s very own American Idol. With all proceeds benefitting local worthy causes, donations ...
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, FACS ... 2017 Top Doctor. The annual list identifies the nation’s top physicians, in a variety ... made it to the top of Castle Connolly’s coveted ranking. , Castle Connolly is ...
Breaking Medicine News(10 mins):
(Date:8/14/2017)... HACKENSACK, N.J. and PETACH TIKVAH, ... Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult ... for the second quarter ending June 30, 2017. ... advanced stages of preparing for our pivotal Phase 3 ... Chaim Lebovits , President and Chief Executive Officer ...
(Date:8/7/2017)... Md. , Aug. 7, 2017 ... healthcare member acquisition, retention, and engagement, announced the ... of Strategy and Product Development, effective as of ... consulting and technology implementation strategy for our clients. ... of experience in consulting and business analytics within ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
Breaking Medicine Technology:
Cached News: