HOME >> MEDICINE >> NEWS
New study suggests that tamoxifen does not adversely impact brain chemistry

Torrance, Calif. (April 11, 2002) Surprising results from a new study may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, suggesting that both tamoxifen and estrogen have similar effects on the brain. The study was conducted at Harbor-UCLA Research & Education Institute (REI) in Torrance, California by research collaborators Rowan Chlebowski, M.D., Ph.D. and Thomas Ernst, Ph.D. and Linda Chang, M.D., of Brookhaven National Laboratory in New York. The findings will be published in the April 17 issue of the Journal of the National Cancer Institute and promise to advance breast cancer risk reduction as an achievable medical objective in the near future.

Based on the increase in hot flashes that are associated with tamoxifen, it has been suggested that the drug blocks the potentially favorable effects of estrogen on the brain. Weve found just the opposite, said Dr. Chlebowski. We were surprised to find similarities between the two groups in that women who have been treated with tamoxifen had lower levels of myo-inositol, a chemical that increases in response to brain injury. Women who took estrogen also had lower levels of the chemical, he added.

This study is unique in that it uses Proton Magnetic Resonance Spectroscopy (MRS), a non-radioactive brain imaging technique to measure levels of cerebral metabolites in this case myo-inositol to predict the effects of tamoxifen. The study compared levels of myo-inositol in 16 breast cancer survivors who had been treated with tamoxifen for at least two years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least two years, and 33 healthy women who had not received any treatment.

Study participants were between the ages of 65 and 80 who did not have any neurologic diseases. Dr. Chlebowski and his collaborators concluded that both tamoxifen and estrogen may be neuroprotective and may have favorable
'"/>

Contact: Barbara Kerr
bkerr@rei.edu
310-222-2820
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
16-Apr-2002


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology:
Cached News: