HOME >> MEDICINE >> NEWS
New study suggests that tamoxifen does not adversely impact brain chemistry

Torrance, Calif. (April 11, 2002) Surprising results from a new study may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, suggesting that both tamoxifen and estrogen have similar effects on the brain. The study was conducted at Harbor-UCLA Research & Education Institute (REI) in Torrance, California by research collaborators Rowan Chlebowski, M.D., Ph.D. and Thomas Ernst, Ph.D. and Linda Chang, M.D., of Brookhaven National Laboratory in New York. The findings will be published in the April 17 issue of the Journal of the National Cancer Institute and promise to advance breast cancer risk reduction as an achievable medical objective in the near future.

Based on the increase in hot flashes that are associated with tamoxifen, it has been suggested that the drug blocks the potentially favorable effects of estrogen on the brain. Weve found just the opposite, said Dr. Chlebowski. We were surprised to find similarities between the two groups in that women who have been treated with tamoxifen had lower levels of myo-inositol, a chemical that increases in response to brain injury. Women who took estrogen also had lower levels of the chemical, he added.

This study is unique in that it uses Proton Magnetic Resonance Spectroscopy (MRS), a non-radioactive brain imaging technique to measure levels of cerebral metabolites in this case myo-inositol to predict the effects of tamoxifen. The study compared levels of myo-inositol in 16 breast cancer survivors who had been treated with tamoxifen for at least two years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least two years, and 33 healthy women who had not received any treatment.

Study participants were between the ages of 65 and 80 who did not have any neurologic diseases. Dr. Chlebowski and his collaborators concluded that both tamoxifen and estrogen may be neuroprotective and may have favorable
'"/>

Contact: Barbara Kerr
bkerr@rei.edu
310-222-2820
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
16-Apr-2002


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... Dayton, NJ (PRWEB) , ... May 26, 2017 , ... ... in Fort Lee, New Jersey School District had left education officials with a number ... removal and replacement of the flooring had to be accomplished with little or no ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a leader in ... a one-day technology conference in San Diego, CA. , At nVerge 2017, Altec ... fully utilize and enhance their Sage ERP solutions by providing improved visibility and control ...
(Date:5/24/2017)... Cortland, OH (PRWEB) , ... May 24, 2017 , ... ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, ... smiles while simultaneously improving their oral health and functionality. , Dr. Bedich ...
(Date:5/24/2017)... Clarkston, Lake Orion, Michigan (PRWEB) , ... ... ... Endometriosis is a disease affecting the female reproductive tract in which the ... on the pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... offering holistic pediatric dentistry options for its patients on Long Island, New York. ... entire physical well being, and is one of the biggest trends in dentistry ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... May 22, 2017  Lilac Corp, the company ... the launch of a new website . ... of a clinical study that showed surprising clearance ... Gene-Eden-VIR/Novirin in individuals suffering from HPV warts, precancerous, ... there are no other treatments that clear the ...
(Date:5/18/2017)... May 18, 2017  Two Bayer U.S. Pharmaceutical leaders ... during its recent 28 th Woman of ... event showcases HBA,s longstanding mission of furthering the advancement ... Cindy Powell-Steffen , senior director of ... division, and Libby Howe , a regional business ...
(Date:5/15/2017)... 2017  Amy Baxter MD, chief executive officer and ... pain relief, was awarded a 2017 Top 40 Healthcare ... recognized at the MM&M Top 40 Healthcare Transformers dinner ... on May 10, 2017. The dinner followed a ... "beyond the pill."  "Innovation goes beyond invention," ...
Breaking Medicine Technology:
Cached News: