New substance that improves the photodetection of bladder cancer gains marke...( d because its further metabolism is slo...)

New substance that improves the photodetection of bladder cancer gains market approval

d because its further metabolism is slowed down in cancer cells, photoactive porhyrins accumulate to the point where the fluorescent effect can be used clinically. These accumulations are harmless because within 24 hours the body naturally eliminates all traces of the molecule.

Ex vivo and clinical optimization studies using hexaminolevulinate were carried out in collaboration with Pavel Kucera from the Institute of Physiology of the University of Lausanne and Patrice Jichlinski from the department of Urology at the University Hospital in Lausanne.

The development of Hexvix now means that a strong fluorescent signal can be obtained with short installation times in the bladder. Hexvix has no observed systemic or local side effects.

Photodetection using Hexvix has undergone extensive clinical trials in several European countries, including Switzerland, Germany, Sweden and Norway. Clinical studies aiming at obtaining similar marketing authorization in the US are ongoing.

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Contact: Mary Parlange, science writer
mary.parlange@epfl.ch
41-21-693-7022
Ecole Polytechnique Fdrale de Lausanne
2-Mar-2005

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New substance that improves the photodetection of bladder cancer gains marke...( d because its further metabolism is slo...),Health