The findings appear in the October issue of Neuropsychology, which is published by the American Psychological Association (APA).
Diffusion tensor imaging (DTI) uses a regular MRI machine to analyze the movement of water molecules in and around the fibers that connect different parts of the brain. Neuroscientists use DTI to track indicators of brain "connectivity" factors such as the number, thickness, density and arrangement of axons (the hair-like extensions of neurons, which send messages to other neurons) and thickness of the insulating/conducting fatty myelin sheath in which they are embedded. If weaker structural integrity reduces connectivity, lead author Paul Nestor, PhD, says it may mean that, "different brain areas do not communicate as well with less synchrony or harmony, akin to an orchestra or band playing out of synch."
The researchers conducted neuropsychological tests on 41 patients with schizophrenia and 46 healthy controls, and used DTI scans on a 14-person subset of people with schizophrenia and healthy controls, a sample size typical of seminal studies of the human brain and comparable to early studies using functional MRI.
Brain images from the schizophrenic patients showed abnormalities in two functionally and anatomically different neural pathways the uncinate fasciculus (UF) and the cingulate bundle (CB). Compared with age-matched controls, patients had small
Contact: Pam Willenz
American Psychological Association