New treatment appears effective f...( a reduction in redness vs. 42 percent ...),Health

a reduction in redness vs. 42 percent of the metronidazole gel group. The researchers also found that the effectiveness of the metronidazole gel seemed to plateau after 8 weeks, while patients in the azelaic acid gel group showed continuous improvement over 15 weeks.

The researchers conclude: "Results showed that azelaic acid gel was consistently superior to metronidazole gel in improving principal signs of rosacea (for example, reducing inflammatory papules and pustules and reducing erythema [redness] intensity). In addition, azelaic acid gel was superior to metronidazole gel in improving or resolving rosacea signs as measured by two distinct investigators' assessments."

" these results suggest a beneficial effect of azelaic acid during prolonged treatment periods, warranting further investigation of long-term treatment of rosacea with azelaic acid gel," the authors write.

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Contact: Hank Black
205-934-3884
JAMA and Archives Journals
17-Nov-2003

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