HOME >> MEDICINE >> NEWS
New understanding of a key control mechanism in the brain

REHOVOT, Israel -- January 12, 2000 -- Despite more than a century of research on inhibitory neurons, very little is known on how this small population (10-20% of brain neurons) exerts its controlling effect on the brain. Pivotal for normal brain development, learning, and memory, it is not surprising that inhibitory neurons are involved in most neurological disorders. A recent study at the Weizmann Institute of Science, published in the January 2000 issue of Science, reveals key principles underlying the design and function of this inhibitory system.

By repressing the level of activity in neighboring neurons, inhibitory neurons (I-neurons) prevent the brain from quickly spinning out of control into hyper-excited states or full-blown epilepsy. One of the problems that children with autism and attention deficit hyperactivity disorders (ADHD) have is I-neuron malfunction: their inhibitory system does not effectively suppress unwanted information, impeding their ability to make choices. I-neuron malfunction is involved in memory disorders (such as Alzheimer's disease), neural trauma, and addictions. It also plays a role in a wide range of psychiatric disorders, such as depression, obsessive compulsive disorders, and schizophrenia.

In the past, researchers basically thought that I-neurons just sprayed an inhibitory neurotransmitter called GABA onto their neighbors. But this did not explain how they inhibited the right neurons at exactly the right time and to the right degree. The new study carried out in the laboratory of Prof. Henry Markram of the Weizmann Institute's Neurobiology Department shows how they achieve this.

Controlling the neuron crowd

The research team found new types of I-neurons, revealing that this tiny population is several times more diverse than previously thought. Further, using new methods that they developed, the researchers succeeded in recording directly how individual inhibitory neurons control their neighbors. T
'"/>

Contact: Jeffrey J. Sussman, Asst. V.P. Communications
jeffrey@acwis.org
212-895-7951
American Committee for the Weizmann Institute of Science
12-Jan-2000


Page: 1 2 3

Related medicine news :

1. Monkey pay-per-view study could aid understanding of autism
2. Another step towards understanding the causes of narcolepsy
3. Student nurses need better understanding of poverty-stricken patients
4. Signaling pathway may be key to understanding roots of hypertension
5. Advances in understanding brain circuits responsible for tics in Tourettes shed light on disorder
6. New understanding of neural circuits may help development of thought-controlled prosthetic devices
7. Researchers develop better understanding of tamoxifen resistance in breast cancer patients
8. New study highlights misunderstanding surrounding risks and benefits of tamoxifen
9. Study expands understanding of alcoholic memory disorder
10. Research breakthrough in understanding treatment resistant depression
11. New study provides molecular-level understanding of common anti-malarial drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC (SCP) ... obtaining investment capital for emerging technology companies. SCP has delivered investment events ... in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
(Date:6/24/2016)... ... 24, 2016 , ... Advanced Plastic Surgery Institute ( http://www.advancedplasticsurgeryinstitute.com ... its official Medspa Sponsor. Dr. Josh Olson, a board-certified plastic surgeon, owns the ... Olson says the decision to support the pageant in an official capacity is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Surgical Procedure Volumes: Global Analysis (United States, ... Australia, Canada)" report to their offering. ... an essential tool for healthcare business planners, provides surgical ... looks at surgery trends with an in-depth analysis of ...
Breaking Medicine Technology:
Cached News: