HOME >> MEDICINE >> NEWS
New way of controlling cholesterol may help treat Alzheimer's

A new approach to controlling blood cholesterol levels that is already being investigated to prevent cardiovascular disease also may be a potential treatment for Alzheimer's disease. In their report in the October 14 issue of Neuron, researchers from Massachusetts General Hospital (MGH) show that blocking a pathway that controls the distribution of cholesterol in cells dramatically reduces the number of amyloid plaques in the brains of transgenic mice. Some of the treated mice were much better at learning their way through a maze than were untreated mice.

"We found that this way of reducing cholesterol levels in the brains of living animals both decreased amyloid deposition and improved learning," says the study leader Dora Kovacs, PhD, director of the Neurobiology of Disease Laboratory in the Genetics and Aging Research Unit of MassGeneral Institute for Neurodegenerative Disorders. "As far as we know, this is the first study of cholesterol metabolism's impact on amyloid levels that included cognitive testing."

Researchers have been investigating a potential relationship between cholesterol metabolism and Alzheimer's since it was found that a particular variant of the gene for a protein called apoE significantly increased risk of the disease. Since the apoE protein transports cholesterol, that discovery suggested that disruption of cholesterol handling might cause or worsen the development of the amyloid plaques that characterize Alzheimer's disease. In addition, some epidemiologic studies have suggested that people taking statin drugs to control blood cholesterol have a reduced incidence of Alzheimer's.

In 2001 Kovacs' team showed in cells that the activity of an enzyme called ACAT, which controls whether cholesterol is stored in the cellular membrane or in intracellular droplets, also appears to regulate the formation of amyloid-beta, the protein fragments that make up amyloid plaques. The current study was designed to test tha
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
13-Oct-2004


Page: 1 2 3

Related medicine news :

1. Georgia Medicaid program saves $20 million by controlling use of anti-ulcer drugs
2. Problems controlling anger lead to weight gain for teens
3. Clozapine effective for controlling dyskinesias in people with severe Parkinsons
4. Popular anti-epileptic drug also effective in controlling debilitating symptom of multiple sclerosis
5. Kytril more effective in controlling chemotherapy induced nausea and vomiting
6. HIV vaccine research is best hope for controlling AIDS pandemic
7. Boston University team finds link between high cholesterol and better cognitive performance
8. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
9. McGill researchers identify new way to reduce cholesterol levels
10. Researcher breaks down cholesterol mystery
11. American ethnic groups less likely to have cholesterol controlled

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2019)... ... 18, 2019 , ... She went from learning disabled to honor roll – ... Cheryl Reilly. Those “goofy tests,” performed by Deborah Zelinsky, O.D. , founder of ... had such narrow range of visual awareness, she could only see what was directly ...
(Date:4/18/2019)... (PRWEB) , ... April 18, 2019 , ... ... selecting the best provider for their care. Through the rise of online review ... greater level of interaction and transparency when making important purchasing decisions online. In ...
(Date:4/17/2019)... ... , ... With Fentanyl overdose deaths continuing to claim lives and keeping the ... looking for an alternative to naloxone. Researchers are presenting their findings to the ... (often known by the name brand Narcan) has been utilized increasingly since the opioid ...
(Date:4/17/2019)... ... ... Kadan Homecare, an award-winning provider of quality, non-medical home care to Atlanta area ... Best of Home Care® – Provider of Choice and Employer of Choice Awards from ... based on client and caregiver satisfaction scores gathered by Home Care Pulse. Kadan is ...
(Date:4/17/2019)... ... April 17, 2019 , ... The IBS Patient Support Group, ... to designate April 19th as World IBS Day to raise awareness for Irritable ... in their pursuit to find treatments. Irritable Bowel Syndrome is a common digestive ...
Breaking Medicine News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... KVC ... Outfitters and Tempur Sealy, at Fasig-Tipton horse farm on May 17, 2019 to ... the heart of the Bluegrass, this elegant venue highlights Kentucky's stunning farmland, prized ...
(Date:4/17/2019)... (PRWEB) , ... April 17, 2019 , ... Salt ... 2019 Honorary Doctorate recipients. They will receive their degrees at SLCC’s May 3 Commencement ... is the executive vice president over Corporate Affairs and Miller Family Philanthropy. Richards is ...
(Date:4/17/2019)... ... ... What do you get when you mix healthcare, a video game development internship, and ... the Healthcare Games Showdown™ involves college students creating video games for healthcare from July ... in a livestream show. , Improv comedian host, Scott Gibbs, is ...
Breaking Medicine Technology:
Cached News: