New ways to design safer & more effective topical (transdermal) drug delivery announced i...( in already-crowded lipid bi-layers to d...),Health

in already-crowded lipid bi-layers to disorganize them. Some can also break open the dead cells in the SC and interact with the protein in those cells. CPEs that cause skin irritation are typically associated with the unfolding of proteins in skin cells.

By studying the molecular properties of a CPE, its propensity to penetrate or irritate the skin can be predicted. Simply put, the researchers draw a CPE's structure on a computer, input its molecular properties, and then compute its penetrability or effectiveness and its potential to irritate the skin.

Such computer-aided modeling facilitates the analysis of millions of molecules, allowing researchers to then submit the most promising candidates to further in-vivo laboratory analysis.

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Contact: Barbara Bronson Gray
bbgray@sbcglobal.net
818-889-5415
University of California - Santa Barbara
15-Mar-2005

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