Newer lung cancer treatments extend survival longer than traditional regimens

Patients with advanced non-small cell lung cancer who are treated with regimens containing paclitaxel and carboplatin survive longer than patients treated with older cisplatin-based regimens or supportive care, a new study finds.

"While advanced lung cancer remains incurable, this study provides additional evidence that paclitaxel- and carboplatin-based regimens can prolong survival of patients with this disease," said John Hainsworth, MD, lead study author and Director of Clinical Research at the Sarah Cannon Cancer Center. "Survival beyond two years has been uncommon with previous treatments for advanced non-small cell lung cancer. With these newer regimens, two-year survival is similar to what we used to see at one year with the best supportive care or older regimens."

This study provides long-term follow-up on 321 patients with newly-diagnosed stage IIIB or IV non-small cell lung cancer who were treated in one of three sequential phase II trials between March 1995 and April 1998. All three trials were conducted in The Minnie Pearl Cancer Research Network, a community-based clinical trials group. Each trial included a different treatment regimen: paclitaxel and carboplatin; paclitaxel, carboplatin and gemcitabine; and paclitaxel, carboplatin, and vinorelbine. Data from these trials were compared retrospectively to previous studies on supportive care or traditional cisplatin-based regimens.

After an average follow-up of 58 months, actual one-, two-, and three-year survival rates were 40 percent, 19 percent, and 7 percent, respectively. The actuarial four-year survival rate for the entire group was four percent.

When compared retrospectively to older cisplatin-based regimens (not containing a taxane), these paclitaxel- and carboplatin-based treatments increase one-year survival from 25 to 30 percent, to 35 to 40 percent. These regimens also improve survival substantially when compared to the 16 percent one-year survival rate

Contact: Stacia Momburg
American Society of Clinical Oncology

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