Newly approved psoriasis drug invented and tested at Univ. of Michigan

ANN ARBOR, MI The University of Michigan Health System today welcomed the approval by the U.S. Food and Drug Administration of a psoriasis treatment that was first developed in a U-M Medical School laboratory.

Alefacept, a specially designed molecule that blocks a specific immune-system reaction involved in the painful skin condition, was approved for marketing today under the name Amevive. Biogen, Inc. of Cambridge, Mass., will market the drug.

Alefacept traces its roots to research done at the U-M in the mid-1990s by a team led by former dermatology faculty member Kevin D. Cooper, M.D. The University and Biogen share the patent on the engineered molecule with Cooper, who is now chair of dermatology at Case Western Reserve University in Cleveland.

UMHS also played a major role in the advanced-phase clinical trials that demonstrated alefacept's ability to significantly ease or clear the painful symptoms of psoriasis -- relief that continues even after treatment stops.

Dermatologist Charles Ellis, M.D., who has no financial connection to the patent, was selected to help design and lead the Phase II and III studies because of his long experience studying and treating the immune response in psoriasis. Ellis is associate chair of dermatology at UMHS and chief of dermatology at the VA Ann Arbor Healthcare System.

The results of the phase II trial were published in the July 26, 2001 issue of the New England Journal of Medicine. No patients in the Phase II or III studies were treated at UMHS. Ellis shared leadership of the study with Gerald G. Krueger, M.D., a professor of dermatology at the University of Utah School of Medicine. Biogen, which funded the study, compensates Ellis and Krueger for consulting on the development and testing of the alefacept product.

Psoriasis, which stems from a runaway immune response in the skin, causes skin itching, redness, flaking, pain, and cracking in about 2 percent of the population,

Contact: Kara Gavin
University of Michigan Health System

Page: 1 2 3 4

Related medicine news :

1. Newly discovered pathway might help in design of cancer drugs
2. Newly identified gene cluster on mouse X chromosome provides insights into fertility
3. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
4. Newly-described route to cancer solves a mystery in lung cancer
5. Newly published data show at-home dialysis therapy may benefit more patients
6. Newly revised recommendations affirm medicine
7. Newly Updated HIV Treatment Guidelines For Adults And Adolescents Available On The World Wide Web
8. Osteoporosis Drug Evista (Raloxifene) Cuts Newly Diagnosed, Invasive Breast Cancer Risk By More Than 60 Percent
9. For Patients With Advanced Prostate Cancer, Newly Evaluated Drug May Offer Pain Relief And Mild Delay In Disease Progression
10. Initiative yields effective methods for anthrax detection; RAMP and MIDI, Inc., methods approved
11. FDA-approved drugs shown to lower Alzheimer diseaserelated protein levels in mice

Post Your Comments:

(Date:10/15/2019)... ... 15, 2019 , ... In 2019, Unitek opened its doors to various nursing ... 2018 . Students who started in July were only entering their second term when ... would have to start over. Then the leadership team at Unitek honored their commitment ...
(Date:10/11/2019)... ... October 11, 2019 , ... Inland Detox, Inc. has just moved ... location has incredible views of the Temecula Valley and it’s the perfect place for ... facility offers both private rooms as well as double occupancy rooms, a 2nd home ...
(Date:10/10/2019)... ... October 10, 2019 , ... Caring.com, a leading senior care ... Best and Worst Places for Seniors to Live. All 50 states and 302 cities ... of life and workforce development. , According to the U.S. Census Bureau ...
(Date:10/8/2019)... BEACH, Calif. (PRWEB) , ... October 08, 2019 , ... ... , "We are happy to announce the expansion of our services to better serve ... had the opportunity over this last year to see the extraordinary impact this pre-intervention ...
(Date:10/8/2019)... ... October 08, 2019 , ... Drs. Joel Rosenlicht and Ryaz ... teeth restore their smiles with long-lasting dental implants . Placing over 750 ... 3D Cone Beam CT imaging, X-Guide™ software and Yomi® robotic-assisted technology to plan ...
Breaking Medicine News(10 mins):
(Date:10/9/2019)... ... 09, 2019 , ... The 11th annual American Meditation Institute ... AMI Meditation for the relief and prevention of physician burnout. Entitled The ... at the Cranwell Resort and Spa in Lenox, Massachusetts, is certified by the ...
(Date:10/8/2019)... ... ... Dr. Ryan McNally, ND, MS, PA and Dr. Shashita Inamdar, MD, PhD, ... Their presentation titled Advances in Integrative Neuropsychiatry and Functional Mental Health, will evaluate the ... brain health, and reduce the debilitating symptoms of a range of neuropsychiatric disorders. ...
(Date:10/8/2019)... ... October 08, 2019 , ... Respected oral and maxillofacial surgeon, ... & Maxillofacial Surgery. This cutting-edge practice serves both Washington, PA and Steubenville, OH ... to predictable jaw surgery with 3D imaging. Dr. Humberger was honored to join ...
Breaking Medicine Technology:
Cached News: