HOME >> MEDICINE >> NEWS
Newly identified gene cluster on mouse X chromosome provides insights into fertility

HOUSTON - Researchers at The University of Texas M. D. Anderson Cancer Center have discovered a cluster of 12 genes on the X chromosome in mice that appears to play an important role in reproduction. Reporting in the journal Cell, the scientists showed that knocking out just one of the genes resulted in reduced fertility in male mice.

The researchers found the cluster, which they dubbed the reproductive homeobox X-linked (or Rhox) genes, is selectively expressed in male and female reproductive tissues in adult mice.

Although the team cannot yet say that the discovery has any corollary to human biology, they already have found two versions of mouse Rhox genes on the human X chromosome - they are both expressed in human testes.

"Little is known about the causes of human infertility, and that is why we are acutely interested in the Rhox findings," says the study's lead investigator, Miles Wilkinson, Ph.D., a professor in the Department of Immunology. "Conversely, we are intrigued by the notion that these Rhox genes also might be useful tools for developing new contraceptive methods - either in men or women."

Wilkinson earlier had discovered the founding member of this Rhox gene cluster, the Pem gene - now called Rhox5 - which, while normally restricted in expression to reproductive tissues, is aberrantly expressed in a wide variety of tumors, including carcinomas, sarcomas and lymphomas.

Pem and the other Rhox genes belong to a class of so-called "homeobox" genes that all share a common stretch of DNA sequence. Homeobox genes are known to encode transcription factors - their job is to turn other genes on. But because most of the estimated 200 homeobox genes that have been identified in mammals are solitary, Wilkinson says it was quite a surprise to find that the Rhox genes were grouped together in a large cluster. The only other significantly sized homeobox gene cluster known is the Hox gene cluster, which was discovered more tha
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
10-Feb-2005


Page: 1 2 3

Related medicine news :

1. Newly discovered pathway might help in design of cancer drugs
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly-described route to cancer solves a mystery in lung cancer
4. Newly approved psoriasis drug invented and tested at Univ. of Michigan
5. Newly published data show at-home dialysis therapy may benefit more patients
6. Newly revised recommendations affirm medicine
7. Newly Updated HIV Treatment Guidelines For Adults And Adolescents Available On The World Wide Web
8. Osteoporosis Drug Evista (Raloxifene) Cuts Newly Diagnosed, Invasive Breast Cancer Risk By More Than 60 Percent
9. For Patients With Advanced Prostate Cancer, Newly Evaluated Drug May Offer Pain Relief And Mild Delay In Disease Progression
10. New marker for early diagnosis of kidney failure identified
11. Protein that helps skin cancer spread identified by Stanford researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 05, 2018 , ... Headquartered in Bedford Park, Illinois, United ... August 3, 2018, the federal Department of Health and Human Services released ... notable part of this rule, which takes effect on October 2, 2018, is increasing ...
(Date:10/5/2018)... ... ... The American Orthopaedic Society for Sports Medicine ( AOSSM ) is proud ... passage of the Sports Medicine Licensure Clarity Act (H.R.302) which was signed into law ... legal protection for traveling team physicians and safeguards injured athletes’ timely access to the ...
(Date:10/5/2018)... (PRWEB) , ... October 05, 2018 , ... From flu shots to a Halloween costume ... a scary good variety of healthy treats for people of all ages. , The Steward ... grand opening celebration on Thursday, October 18. Providers at the clinic will offer flu immunizations ...
(Date:10/3/2018)... MILWAUKEE (PRWEB) , ... October 03, 2018 , ... ... first mobile clinical tool to allow OB/GYNs to remotely monitor their pregnant patients’ ... the Froedtert & Medical College of Wisconsin health network (MCW). Patients who choose ...
(Date:10/3/2018)... ... October 03, 2018 , ... On September 7, 2018, ... to help children fight cancer. Co-founded by sisters-in-law Eliza Glants and Alisa Tovmanyan, ... to raise awareness for children's healthcare. A portion of proceeds from each pastel-colored ...
Breaking Medicine News(10 mins):
(Date:10/7/2018)... , ... October 07, 2018 , ... No one likes to think about an emergency, ... can be disruptive to a family. The local ServPro professional, a trusted leader in the ... shocks of an emergency. , No time is a good time for an emergency, ...
(Date:10/6/2018)... ... October 06, 2018 , ... Number One ... One On The List services improve search engine ranking - clients get found ... Press Releases, Marketing Programs, Email Newsletters, SEO, Packages of Services and more. , ...
(Date:10/5/2018)... ... ... article in the Richmond Times-Dispatch reports on the death of a 24 year-old Dallas ... of a head trauma. As the article points out, the tragedy comes in the wake ... for adults. Los Angeles based personal injury law firm Legal Defenders at ...
Breaking Medicine Technology:
Cached News: